AAB25452.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,746 Da
NCBI Official Full Name
betacellulin
NCBI Official Synonym Full Names
betacellulin
NCBI Protein Information
probetacellulin
UniProt Protein Name
Probetacellulin
UniProt Synonym Gene Names
UniProt Entry Name
BTC_HUMAN
NCBI Summary for BTC
This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients. [provided by RefSeq, Nov 2015]
UniProt Comments for BTC
BTC: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
Protein type: Ligand, receptor tyrosine kinase; Cell cycle regulation; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q13.3
Cellular Component: extracellular region; extracellular space
Molecular Function: phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity
Biological Process: epidermal growth factor receptor signaling pathway; MAPKKK cascade; phosphoinositide-mediated signaling; positive regulation of cell proliferation; regulation of phosphoinositide 3-kinase cascade
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