NP_001106650.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
119,563 Da
NCBI Official Full Name
mitotic checkpoint serine/threonine-protein kinase BUB1 isoform 1
NCBI Official Synonym Full Names
budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)
NCBI Official Synonym Symbols
Bub1a; C80208; D2Xrf87; AL022991 [Similar Products]
NCBI Protein Information
mitotic checkpoint serine/threonine-protein kinase BUB1; mBUB1
UniProt Protein Name
Mitotic checkpoint serine/threonine-protein kinase BUB1
UniProt Synonym Protein Names
BUB1A
UniProt Synonym Gene Names
UniProt Entry Name
BUB1_MOUSE
UniProt Comments for BUB1
BUB1: a mitotic-checkpoint protein kinase of the BUB family. Autophosphorylated when the cells enters mitosis. Kinetochore localization is required for normal mitotic timing and checkpoint response to spindle damage. High expression in testis and thymus, less in colon, spleen, lung and small intestine. Expressed in fetal thymus, bone marrow, heart, liver, spleen and thymus. Expression is associated with cells/tissues with a high mitotic index. LOF mutations seen in two colon cancer cell lines exhibiting chromosomal instability, in several leukemias and lymphomas, and in a pancreatic cancer cell line. BUB1 functions in mitotic spindle assembly, and may cause chromosomal instability. In mouse BRCA2 knockouts, mutations in BUB1 and BUBR1 are frequently seen in the resulting tumors. BUB1 and BUBR1 are overexpressed, but not mutated, in many gastric cancers.
Protein type: Protein kinase, Ser/Thr (non-receptor); Cell cycle regulation; Kinase, protein; EC 2.7.11.1; Protein kinase, Other; Other group; BUB family
Cellular Component: nucleoplasm; kinetochore; membrane; cytoplasm; chromosome; nucleus; chromosome, pericentric region; condensed nuclear chromosome, pericentric region
Molecular Function: transferase activity; protein serine/threonine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; ATP binding; protein kinase activity
Biological Process: mitosis; embryonic development; cell division; apoptosis; regulation of chromosome segregation; regulation of sister chromatid cohesion; cell cycle; phosphorylation; protein amino acid phosphorylation; chromosome segregation
Research Articles on BUB1
Precautions
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Disclaimer
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Pathways associated with BUB1 elisa kit
Diseases associated with BUB1 elisa kit
Organs/Tissues associated with BUB1 elisa kit
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