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BXA1 recombinant protein :: Botulinum neurotoxin type A Recombinant Protein

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Catalog # MBS9420883
Unit / Price
  0.01 mg  /  $265 +1 FREE 8GB USB
  0.05 mg  /  $350 +1 FREE 8GB USB
  0.1 mg  /  $560 +1 FREE 8GB USB
  0.2 mg  /  $880 +1 FREE 8GB USB
  0.5 mg  /  $1,145 +1 FREE 8GB USB
  1 mg  /  $1,795 +2 FREE 8GB USB
BXA1 recombinant protein
Product Name

Botulinum neurotoxin type A (BXA1), Recombinant Protein

Popular Item
Also Known As

Recombinant Clostridium botulinum Botulinum neurotoxin type A

Product Synonym Names
Bontoxilysin-A; BOTOX
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
Full Length, 1-436aa
3D Structure
ModBase 3D Structure for P10845
Host
E Coli
Species Reactivity
CLOBO
Purity/Purification
Greater than 90% as determined by SDS-PAGE.
Form/Format
20mM Tris-HCl based buffer, pH8.0
Tag Info
His-SUMO-tag
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
Other Notes
Small volumes of BXA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
BXA1 recombinant protein
Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic mbrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure.
NCBI/Uniprot data below describe general gene information for BXA1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
Molecular Weight
65.94kD
NCBI Official Full Name
peptidase M27
UniProt Protein Name
Botulinum neurotoxin type A
UniProt Synonym Protein Names
Bontoxilysin-A; BOTOX
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
atx; bna; BoNT/A; BOTOX  [Similar Products]
UniProt Comments for BXA1
Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withBXA1 recombinant protein
 Reference Product  PubMed Publications
 ntnH recombinant protein  >2 publications with BXA1 and ntnH
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