NP_004355.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37,561 Da
NCBI Official Full Name
CCAAT/enhancer-binding protein alpha
NCBI Official Synonym Full Names
CCAAT/enhancer binding protein (C/EBP), alpha
NCBI Protein Information
CCAAT/enhancer-binding protein alpha
UniProt Protein Name
CCAAT/enhancer-binding protein alpha
UniProt Synonym Gene Names
UniProt Entry Name
CEBPA_HUMAN
NCBI Summary for C/EBP-alpha
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. [provided by RefSeq, Jul 2008]
UniProt Comments for C/EBP-alpha
C/EBP-alpha: a bZIP transcription factor which can form homodimers or heterodimers with the related proteins CEBP-beta and CEBP-gamma. Binds to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 19q13.1
Cellular Component: Rb-E2F complex; nuclear matrix; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; protein complex binding; transcription factor activity; transcription factor binding
Biological Process: fat cell differentiation; transcription from RNA polymerase II promoter; embryonic placenta development; macrophage differentiation; viral reproduction; response to glucocorticoid stimulus; cell maturation; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; negative regulation of cell proliferation; response to vitamin B2; acute-phase response; inner ear development; cholesterol metabolic process; mitochondrion organization and biogenesis; organ regeneration; generation of precursor metabolites and energy; granulocyte differentiation; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; negative regulation of cyclin-dependent protein kinase activity; liver development; positive regulation of osteoblast differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; white fat cell differentiation; brown fat cell differentiation; positive regulation of fat cell differentiation; positive regulation of transcription from RNA polymerase III promoter; myeloid cell differentiation; positive regulation of transcription from RNA polymerase II promoter; lung development; urea cycle
Disease: Leukemia, Acute Myeloid
Research Articles on C/EBP-alpha
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Products associated with anti-C/EBP-alpha antibody
Pathways associated with anti-C/EBP-alpha antibody
Diseases associated with anti-C/EBP-alpha antibody
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