• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

C-type lectin domain family 10 member A ELISA Kits

C-type lectins (CTLs) are Ca++-dependent glycan-binding proteins (GBPs) that share primary and secondary structural homology in their carbohydrate-recognition domains (CRDs). These proteins have a C-type lectin fold, which is a fold with highly variable protein sequence that is also present in many proteins that do not bind carbohydrates (C-type lectin domain [CTLD]-containing proteins). C-type lectins and proteins with CTLDs are found in all organisms. The large family of C-type lectins includes collectins, selectins, endocytic receptors, and proteoglycans. Although they share structural homology, C-type lectins usually differ significantly in the types of glycans that they recognize with high affinity. The C-type lectin fold has been found in more than 1000 proteins, and it represents a ligand-binding motif that is not necessarily restricted to binding sugars. The C-type lectin fold is unique. It is a compact domain of 110�130 amino acid residues with a double-looped, two-stranded antiparallel _-sheet formed by the amino-and carboxy-terminal residues connected by two _-helices and a three-stranded antiparallel _-sheet. The CRD has two highly conserved disulfide bonds and up to four sites for binding Ca++.

Some of these proteins are secreted and others are transmembrane proteins. They often oligomerize into homodimers, homotrimers, and higher-ordered oligomers, which increases their avidity for multivalent ligands. These proteins function as adhesion and signaling receptors in many immune functions such as inflammation and immunity to tumor and virally infected cells. Overall, the CTLD superfamily is an interesting and fruitful subject for systematic studies of the mechanisms of protein�carbohydrate interactions, as well as other aspects of protein structure and function evolution, such as fold adaptation to bind other ligands.

Showing 1 to 2 of 2 products

Mouse C-Type Lectin Domain Family 10, Member A (CLEC10A) Antibody Pair Kit (with Standard)
Gene Names:
CLEC10A; HML; MGL; HML2; CD301; CLECSF13; CLECSF14
Other Names:
CLEC10-A; Macrophage Lectin 2(Calcium Dependent); C-type lectin superfamily member 14; Macrophage lectin 2; C-type lectin domain family 10 member A isoform 3; C-type lectin domain containing 10A
Host/Reactivities:
Reactivity: Mouse
Applications:
ELISA (EIA), Chemiluminescence Immunoassays (CLIA), ELISPOT, Luminex
Human C-Type Lectin Domain Family 10, Member A (CLEC10A) Antibody Pair Kit (with Standard)
Gene Names:
CLEC10A; HML; MGL; HML2; CD301; CLECSF13; CLECSF14
Other Names:
CLEC10-A; Macrophage Lectin 2(Calcium Dependent); C-type lectin superfamily member 14; Macrophage lectin 2; C-type lectin domain family 10 member A isoform 2; C-type lectin domain containing 10A
Host/Reactivities:
Reactivity: Human
Applications:
ELISA (EIA), Chemiluminescence Immunoassays (CLIA), ELISPOT, Luminex
    Request a Quote

    Please fill out the form below and our representative will get back to you shortly.

    MBS000000
    Contact Us

    Please fill out the form below and our representative will get back to you shortly.

    MBS000000