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C1QB native protein :: Complement C1q Native Protein

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Catalog # MBS537906
Unit / Price
  1 mg  /  $780 +1 FREE 8GB USB
C1QB native protein
Product Name

Complement C1q (C1QB), Native Protein

Also Known As

Complement C1q protein

Product Synonym Names
C1q protein
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
3D Structure
ModBase 3D Structure for P02746
> 96% pure
Lyophilized from 0.01M Na2EDTA, pH 7.5, with 0.3M NaCl.
Source Note
Human plasma
Protein Type
Biological Significance
Complement C1q is a 400kDa protein formed from 18 peptide chains in 3 subunits of 6. Each 6 peptide subunit consists of a Y-shaped pair of triple peptide helices joined at the stem and ending in a globular non-helical head. The C1q complex is potentially multivalent for attachment to the complement fixation sites of immunoglobulin.The appropriate peptide sequence of the complement fixing site might become exposed following complexing of the immunoglobulin, or the sites might always be available, but might require multiple attachment by C1q with critical geometry in order to achieve the necessary avidity.
None detected by SDS PAGE analysis
Preparation and Storage
Store at 4 degree C.
Other Notes
Small volumes of C1QB native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
C1QB native protein
Purified Complement C1q protein isolated from human plasma
NCBI/Uniprot data below describe general gene information for C1QB. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
complement C1q subcomponent subunit B
NCBI Official Synonym Full Names
complement component 1, q subcomponent, B chain
NCBI Official Symbol
NCBI Protein Information
complement C1q subcomponent subunit B
UniProt Protein Name
Complement C1q subcomponent subunit B
UniProt Gene Name
UniProt Entry Name
NCBI Summary for C1QB
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of human complement subcomponent C1q [provided by RefSeq, Jul 2008]
UniProt Comments for C1QB
C1QB: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QB are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.12

Cellular Component: collagen; extracellular region; complement component C1 complex

Molecular Function: protein binding; protein homodimerization activity

Biological Process: innate immune response; complement activation, classical pathway; inner ear development; complement activation

Disease: C1q Deficiency
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