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C1QC cdna clone

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Catalog # MBS1267971
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
C1QC cdna clone
Product Name

C1QC, cDNA Clone

Popular Item
Also Known As

C1QC cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
738
Sequence
atggacgtgg ggcccagctc cctgccccac cttgggctga agctgctgct gctcctgctg ctgctgcccc tcaggggcca agccaacaca ggctgctacg ggatcccagg gatgcccggc ctgcctgggg caccagggaa ggatgggtac gacggactgc cggggcccaa gggggagcca ggaatcccag ccattcccgg gatccgagga cccaaagggc agaagggaga acccggctta cccggccatc ctgggaaaaa tggccccatg ggaccccctg ggatgccagg ggtgcccggc cccatgggca tccctggaga gccaggtgag gagggcagat acaagcagaa attccagtca gtgttcacgg tcactcggca gacccaccag ccccctgcac ccaacagcct gatcagattc aacgcggtcc tcaccaaccc gcagggagat tatgacacga gcactggcaa gttcacctgc aaagtccccg gcctctacta ctttgtctac cacgcgtcgc atacagccaa cctgtgcgtg ctgctgtacc gcagcggcgt caaagtggtc accttctgtg gccacacgtc caaaaccaat caggtcaact cgggcggtgt gctgctgagg ttgcaggtgg gcgaggaggt gtggctggct gtcaatgact actacgacat ggtgggcatc cagggctctg acagcgtctt ctccggcttc ctgctcttcc ccgactag
OMIM
120575
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of C1QC cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for C1QC. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,774 Da
NCBI Official Full Name
Homo sapiens complement component 1, q subcomponent, C chain, mRNA
NCBI Official Synonym Full Names
complement C1q C chain
NCBI Official Symbol
NCBI Official Synonym Symbols
C1QG; C1Q-C
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NCBI Protein Information
complement C1q subcomponent subunit C
UniProt Protein Name
Complement C1q subcomponent subunit C
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
C1QC_HUMAN
NCBI Summary for C1QC
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for C1QC
C1QC: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QC are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: extracellular region; extracellular space

Molecular Function: serine-type endopeptidase activity

Biological Process: complement activation; complement activation, classical pathway; negative regulation of granulocyte differentiation; negative regulation of macrophage differentiation

Disease: C1q Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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