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C7 native protein :: Complement C7 Native Protein

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Catalog # MBS537072
Unit / Price
  0.25 mg  /  $485 +1 FREE 8GB USB
C7 native protein
Product Name

Complement C7, Native Protein

Popular Item
Also Known As

Complement C7 protein

Product Synonym Names
C& protein
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
843
OMIM
217070
3D Structure
ModBase 3D Structure for P10643
Host
Human
Purity/Purification
> 98% pure
Form/Format
Supplied as a liquid in PBS, pH 7.2, no preservatives added.
Source Note
Human serum/plasma
Protein Type
Native
Biological Significance
Native human C7 is a naturally glycosylated protein composed of a single polypeptide chain of 92,400 Da. C7 is essential for formation of the membrane attack complex (MAC) and is activated non-proteolytically by binding to recently-formed C5b,C6 complexes at the cell membrane. Each pathway of complement activation generates proteolytic enzyme complexes (C3/C5 convertases) which are bound to the target surface.
Biohazard Information
Donor samples were tested and found to be negative for HBsAg, HTLV-I/II, STS, and for antibodies to HCV, HIV-1 and HIV-II. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Aliquot and store at -70 degree C or lower. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of C7 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
C7 native protein
Purified Complement C7 protein isolated from human plasma
NCBI/Uniprot data below describe general gene information for C7. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
complement component C7
NCBI Official Synonym Full Names
complement component 7
NCBI Official Symbol
NCBI Protein Information
complement component C7
UniProt Protein Name
Complement component C7
Protein Family
UniProt Gene Name
UniProt Entry Name
CO7_HUMAN
NCBI Summary for C7
C7 is a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. [provided by RefSeq, Jul 2008]
UniProt Comments for C7
C7: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor. Defects in C7 are a cause of complement component 7 deficiency (C7D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 5p13

Cellular Component: membrane attack complex; extracellular region

Biological Process: cellular sodium ion homeostasis; cytolysis; complement activation, alternative pathway; regulation of complement activation; innate immune response; complement activation, classical pathway; complement activation

Disease: Complement Component 7 Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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