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C9 native protein :: Complement C9 Native Protein

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Catalog # MBS537887
Unit / Price
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  0.25 mg  /  $485 +1 FREE 8GB USB
C9 native protein
Product Name

Complement C9, Native Protein

Popular Item
Full Product Name

Complement C9 protein

Product Synonym Names
C9 protein
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P02748
> 95% pure
Supplied as a liquid in PBS, pH 7.2, no preservatives added,
1.05mg/ml (lot specific)
Human serum/plasma
Protein Type
Biological Significance
Native human C9 is a naturally glycosylated (7.8%) protein composed of a single polypeptide chain. The molecular weight is 71,000 Da. C9 binds to the C5b-8 complex and forms the mature membrane attack complex (MAC) on cell membranes. Each pathway of complement activation generates proteolytic enzyme complexes (C3/C5 convertases) which are bound to the target surface. These enzymes cleave a peptide bond in the larger alpha chain of C5 releasing the anaphylatoxin C5a and activating C5b.
Biohazard Information
Use appropriate laboratory precautions when handling this product
Functional Activity
462,000 U/mg, >100% of C9 in NHS on a mg/mg basis.
Preparation and Storage
Upon receipt store at -70 degree C. Avoid repeated freeze/thaw cycles.
Shipping: Ships with Dry Ice.
Other Notes
Small volumes of C9 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
C9 native protein
Purified Complement C9 protein isolated from human plasma
Application Notes for C9 native protein
NCBI/Uniprot data below describe general gene information for C9. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
complement component C9
NCBI Official Synonym Full Names
complement component 9
NCBI Official Symbol
NCBI Official Synonym Symbols
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NCBI Protein Information
complement component C9
UniProt Protein Name
Complement component C9
Protein Family
UniProt Gene Name
UniProt Entry Name
NCBI Summary for C9
This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. [provided by RefSeq, Feb 2009]
UniProt Comments for C9
C9: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC. Defects in C9 are a cause of complement component 9 deficiency (C9D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Apoptosis; Extracellular matrix

Chromosomal Location of Human Ortholog: 5p14-p12

Cellular Component: membrane attack complex; integral to plasma membrane; cytoplasm; extracellular region; plasma membrane

Biological Process: complement activation, alternative pathway; regulation of complement activation; innate immune response; hemolysis by symbiont of host red blood cells; complement activation, classical pathway

Disease: Macular Degeneration, Age-related, 15; Complement Component 9 Deficiency
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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