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CACNA1F elisa kit :: Human calcium channel, voltage-dependent, L type, alpha 1F subunit ELISA Kit

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Catalog # MBS9336419
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CACNA1F elisa kit
Product Name

calcium channel, voltage-dependent, L type, alpha 1F subunit (CACNA1F), ELISA Kit

Full Product Name

Human Voltage-dependent L-type calcium channel subunit alpha-1F, CACNA1F ELISA Kit

Product Synonym Names
Human Voltage-dependent L-type calcium channel subunit alpha-1F (CACNA1F) ELISA kit; AIED; COD3; COD4; CORDX; CORDX3; CSNB2; CSNB2A; CSNBX2; Cav1.4; JM8; JMC8; OA2; Cav1.4alpha1; calcium channel; voltage-dependent; L type; alpha 1F subunit
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
3D Structure
ModBase 3D Structure for O60840
Species Reactivity
Preparation and Storage
Store all reagents at 2-8 degree C
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of CACNA1F elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for CACNA1Fpurchase
MBS9336419 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the calcium channel, voltage-dependent, L type, alpha 1F subunit (CACNA1F) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CACNA1F. The ELISA analytical biochemical technique of the MBS9336419 kit is based on CACNA1F antibody-CACNA1F antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CACNA1F antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CACNA1F. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
NCBI/Uniprot data below describe general gene information for CACNA1F. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
220,678 Da
NCBI Official Full Name
voltage-dependent L-type calcium channel subunit alpha-1F isoform 2
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, L type, alpha 1F subunit
NCBI Official Symbol
CACNA1F  [Similar Products]
NCBI Official Synonym Symbols
JM8; OA2; AIED; COD3; COD4; JMC8; CORDX; CSNB2; CORDX3; CSNB2A; CSNBX2; Cav1.4; Cav1.4alpha1
  [Similar Products]
NCBI Protein Information
voltage-dependent L-type calcium channel subunit alpha-1F; voltage-gated calcium channel subunit alpha Cav1.4
UniProt Protein Name
Voltage-dependent L-type calcium channel subunit alpha-1F
UniProt Synonym Protein Names
Voltage-gated calcium channel subunit alpha Cav1.4
UniProt Gene Name
CACNA1F  [Similar Products]
UniProt Synonym Gene Names
CACNAF1  [Similar Products]
UniProt Entry Name
NCBI Summary for CACNA1F
This gene encodes a multipass transmembrane protein that functions as an alpha-1 subunit of the voltage-dependent calcium channel, which mediates the influx of calcium ions into the cell. The encoded protein forms a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Mutations in this gene can cause X-linked eye disorders, including congenital stationary night blindness type 2A, cone-rod dystropy, and Aland Island eye disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2013]
UniProt Comments for CACNA1F
CACNA1F: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Defects in CACNA1F are the cause of congenital stationary night blindness type 2A (CSNB2A). Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. Defects in CACNA1F are the cause of cone-rod dystrophy X- linked type 3 (CORDX3). CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. Defects in CACNA1F are the cause of Aaland island eye disease (AIED); also known as Forsius-Eriksson type ocular albinism. On the Aaland island in the Baltic Sea, AIED is an X-linked recessive retinal disease characterized by a combination of fundus hypopigmentation, decreased visual acuity due to foveal hypoplasia, nystagmus, astigmatism, protan color vision defect, myopia, and defective dark adaptation. Except for progression of axial myopia, the disease can be considered to be a stationary condition. Electroretinography reveals abnormalities in both photopic and scotopic functions. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1F subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: photoreceptor outer segment; integral to membrane; voltage-gated calcium channel complex; perikaryon

Molecular Function: voltage-gated calcium channel activity; metal ion binding; high voltage-gated calcium channel activity

Biological Process: cellular calcium ion homeostasis; visual perception; axonogenesis; retina development in camera-type eye; regulation of T cell receptor signaling pathway; dendrite morphogenesis; detection of light stimulus involved in visual perception; T cell homeostasis

Disease: Night Blindness, Congenital Stationary, Type 2a; Cone-rod Dystrophy, X-linked, 3; Aland Island Eye Disease
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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