NP_001243718.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
220,678 Da
NCBI Official Full Name
voltage-dependent L-type calcium channel subunit alpha-1F isoform 2
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, L type, alpha 1F subunit
NCBI Official Synonym Symbols
JM8; OA2; AIED; COD3; COD4; JMC8; CORDX; CSNB2; CORDX3; CSNB2A; CSNBX2; Cav1.4; Cav1.4alpha1 [Similar Products]
NCBI Protein Information
voltage-dependent L-type calcium channel subunit alpha-1F; voltage-gated calcium channel subunit alpha Cav1.4
UniProt Protein Name
Voltage-dependent L-type calcium channel subunit alpha-1F
UniProt Synonym Protein Names
Voltage-gated calcium channel subunit alpha Cav1.4
UniProt Synonym Gene Names
UniProt Entry Name
CAC1F_HUMAN
NCBI Summary for CACNA1F
This gene encodes a multipass transmembrane protein that functions as an alpha-1 subunit of the voltage-dependent calcium channel, which mediates the influx of calcium ions into the cell. The encoded protein forms a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Mutations in this gene can cause X-linked eye disorders, including congenital stationary night blindness type 2A, cone-rod dystropy, and Aland Island eye disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2013]
UniProt Comments for CACNA1F
CACNA1F: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Defects in CACNA1F are the cause of congenital stationary night blindness type 2A (CSNB2A). Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. Defects in CACNA1F are the cause of cone-rod dystrophy X- linked type 3 (CORDX3). CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. Defects in CACNA1F are the cause of Aaland island eye disease (AIED); also known as Forsius-Eriksson type ocular albinism. On the Aaland island in the Baltic Sea, AIED is an X-linked recessive retinal disease characterized by a combination of fundus hypopigmentation, decreased visual acuity due to foveal hypoplasia, nystagmus, astigmatism, protan color vision defect, myopia, and defective dark adaptation. Except for progression of axial myopia, the disease can be considered to be a stationary condition. Electroretinography reveals abnormalities in both photopic and scotopic functions. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1F subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xp11.23
Cellular Component: photoreceptor outer segment; integral to membrane; voltage-gated calcium channel complex; perikaryon
Molecular Function: voltage-gated calcium channel activity; metal ion binding; high voltage-gated calcium channel activity
Biological Process: cellular calcium ion homeostasis; visual perception; axonogenesis; retina development in camera-type eye; regulation of T cell receptor signaling pathway; dendrite morphogenesis; detection of light stimulus involved in visual perception; T cell homeostasis
Disease: Night Blindness, Congenital Stationary, Type 2a; Cone-rod Dystrophy, X-linked, 3; Aland Island Eye Disease
Research Articles on CACNA1F
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Pathways associated with CACNA1F elisa kit
Diseases associated with CACNA1F elisa kit
Organs/Tissues associated with CACNA1F elisa kit
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