AAC21458.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,228 Da
NCBI Official Full Name
calcyclin binding protein
NCBI Official Synonym Full Names
calcyclin binding protein
NCBI Protein Information
calcyclin-binding protein
UniProt Protein Name
Calcyclin-binding protein
UniProt Synonym Protein Names
S100A6-binding protein; Siah-interacting protein
UniProt Synonym Gene Names
UniProt Entry Name
CYBP_HUMAN
NCBI Summary for CACYBP
The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CACYBP
CACYBP: a nuclear/cytoplasmic protein involved in calcium-dependent ubiquitination and proteosomal degradation of target proteins. A possible molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). Interacts with proteins of the S100 family at physiological calcium concentrations. Component of some large E3 complexes and interacts directly with SIAH1, SIAH2 and SKP1A. Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated. Two alternatively spliced isoforms have been described.
Protein type: Adaptor/scaffold; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 1q24-q25
Cellular Component: nucleoplasm; neuron projection; nuclear envelope lumen; cytoplasm; beta-catenin destruction complex
Molecular Function: protein binding; protein homodimerization activity
Biological Process: cardiac muscle cell differentiation; positive regulation of DNA replication; aging
Research Articles on CACYBP
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Products associated with CACYBP clia kit
Pathways associated with CACYBP clia kit
Organs/Tissues associated with CACYBP clia kit
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