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CACYBP recombinant protein :: Calcyclin Binding Recombinant Protein

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Catalog # MBS143953
Unit / Price
  0.005 mg  /  $140 +1 FREE 8GB USB
  0.025 mg  /  $205 +1 FREE 8GB USB
  1 mg  /  $2,235 +2 FREE 8GB USB
CACYBP recombinant protein
Product Name

Calcyclin Binding (CACYBP), Recombinant Protein

Also Known As

Recombinant Human Calcyclin Binding Protein

Product Synonym Names
CACYBP Human; Calcyclin Binding Protein Human Recombinant; S100A6BP; S100A6 Binding Protein; GIG5; PNAS-107; RP1-102G20.6; SIP; CACYBP; hCacyBP; Siah-interacting protein; MGC87971
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
185
Sequence
MGSSHHH HHH SSGLVPRGSH MQQKSQKKAE LLDNEKPAAV VAPITTGYTV KISNYGWDQS DKFVKIYITL TGVHQVPTEN VQVHFTERSF DLLVKNLNGK SYSMIVNNLL KPISVEGSSK KVKTDTVLIL CRKKVENTRW DYLTQVEKEC KEKEKPSYDT ETDPSEGLMN VLKKIYEDGD DDMKRTINKA WVESREKQAK GDTEF
OMIM
606186
3D Structure
ModBase 3D Structure for Q9HB71
Host
E Coli
Purity/Purification
Greater than 85% as determined by SDS-PAGE.
Form/Format
CACYBP Human solution containing 20mM Trsi HCL pH-8, 1mM DTT, 0.1M NaCl & 10% glycerol.
Sterile filtered colorless solution.
Preparation and Storage
CACYBP Human although stable at 4 degree C for 1 week, should be stored desiccated below -18 degree C. Please prevent freeze thaw cycles.
Other Notes
Small volumes of CACYBP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CACYBP recombinant protein
Description: CACYBP Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 205 amino acids (1-185a.a.) and having a molecular mass of 23.4 kDa. CACYBP protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography.

Introduction: CACYBP (calcyclin binding protein) participates in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. CACYBP acts as a molecular bridge in ubiquitin E3 complexes. CACYBP is involved in the ubiquitin-mediated degradation of beta-catenin.
NCBI/Uniprot data below describe general gene information for CACYBP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,228 Da
NCBI Official Full Name
calcyclin-binding protein isoform 2
NCBI Official Synonym Full Names
calcyclin binding protein
NCBI Official Symbol
CACYBP  [Similar Products]
NCBI Official Synonym Symbols
SIP; GIG5; PNAS-107; S100A6BP
  [Similar Products]
NCBI Protein Information
calcyclin-binding protein; S100A6-binding protein; Siah-interacting protein (SIP); growth-inhibiting gene 5 protein; hCacyBP
UniProt Protein Name
Calcyclin-binding protein
UniProt Synonym Protein Names
S100A6-binding protein; Siah-interacting protein
Protein Family
UniProt Gene Name
CACYBP  [Similar Products]
UniProt Synonym Gene Names
S100A6BP; SIP; CacyBP; hCacyBP  [Similar Products]
UniProt Entry Name
CYBP_HUMAN
NCBI Summary for CACYBP
The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CACYBP
CACYBP: a nuclear/cytoplasmic protein involved in calcium-dependent ubiquitination and proteosomal degradation of target proteins. A possible molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). Interacts with proteins of the S100 family at physiological calcium concentrations. Component of some large E3 complexes and interacts directly with SIAH1, SIAH2 and SKP1A. Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated. Two alternatively spliced isoforms have been described.

Protein type: Adaptor/scaffold; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 1q24-q25

Cellular Component: nucleoplasm; neuron projection; nuclear envelope lumen; cytoplasm; beta-catenin destruction complex

Molecular Function: protein binding; protein homodimerization activity

Biological Process: positive regulation of DNA replication; cardiac muscle cell differentiation; aging
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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