• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CALCA purified protein :: KATACALCIN Purified Protein

Scan QR to view Datasheet
Catalog # MBS230172
Unit / Price
  0.1 mg  /  $210 +1 FREE 8GB USB
CALCA purified protein
Product Name

KATACALCIN (CALCA), Purified Protein

Popular Item
Also Known As

SYNTHETIC HUMAN KATACALCIN

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
128
Sequence
Asp-Met-Se r-Ser-Asp- Leu-Glu-Ar g-Asp-His- Arg-Pro-Hi s-Val-Ser- Met-Pro-Gl n-Asn-Ala- Asn
OMIM
114130
3D Structure
ModBase 3D Structure for P01258
Purity/Purification
Purity: >95%
Form/Format
Purified
Purified synthetic peptide - liquid
Concentration
Approximate Protein Concentration: 1.0 mg/ml (lot specific)
Preparation
Solid phase synthesis
Buffer Solution
Acetate buffer
Target Species
Human
Preparation and Storage
Store at -70 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of CALCA purified protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CALCA purified protein
Human Katacalcin, also known as Calcitonin precursor peptide, is a member of the calcitonin gene family. Katacalcin is a calcium-lowering hormone that can significantly lower plasma calcium levels.
Applications Tested/Suitable for CALCA purified protein
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for CALCA. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
2436.9 Da[Similar Products]
NCBI Official Full Name
calcitonin isoform CT preproprotein
NCBI Official Synonym Full Names
calcitonin-related polypeptide alpha
NCBI Official Symbol
CALCA  [Similar Products]
NCBI Official Synonym Symbols
CT; KC; CGRP; CALC1; CGRP1; CGRP-I
  [Similar Products]
NCBI Protein Information
calcitonin; calcitonin gene-related peptide 1; alpha-type CGRP; calcitonin 1; calcitonin gene-related peptide I; calcitonin/calcitonin-related polypeptide, alpha; katacalcin
UniProt Protein Name
Calcitonin
UniProt Synonym Protein Names
Calcitonin carboxyl-terminal peptide; CCP; PDN-21
Protein Family
UniProt Gene Name
CALCA  [Similar Products]
UniProt Synonym Gene Names
CALC1; CCP  [Similar Products]
UniProt Entry Name
CALC_HUMAN
NCBI Summary for CALCA
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
UniProt Comments for CALCA
CALCA: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11p15.2

Cellular Component: extracellular space; cell soma; cytoplasm; extracellular region; terminal button; nucleus

Molecular Function: identical protein binding; protein binding; calcitonin receptor binding; hormone activity; protein complex binding; receptor binding

Biological Process: negative regulation of osteoclast differentiation; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of interleukin-1 alpha production; vasodilation of artery during baroreceptor response to increased systemic arterial blood pressure; response to pain; positive regulation of vasodilation; G-protein signaling, adenylate cyclase activating pathway; protein amino acid phosphorylation; positive regulation of interleukin-8 production; monocyte chemotaxis; leukocyte adhesion; elevation of cytosolic calcium ion concentration; cell-cell signaling; vasculature development; neuropeptide signaling pathway; negative regulation of smooth muscle contraction; regulation of blood pressure; receptor internalization; positive regulation of cAMP biosynthetic process; negative regulation of ossification; feeding behavior; positive regulation of adenylate cyclase activity; negative regulation of blood pressure; negative regulation of bone resorption; positive regulation of macrophage differentiation; inflammatory response; detection of temperature stimulus involved in sensory perception of pain; negative regulation of neurological process; aging; cytosolic calcium ion homeostasis; regulation of heart rate; adenylate cyclase activation; positive regulation of ossification; regulation of systemic arterial blood pressure by neurological process; G-protein coupled receptor internalization; response to heat; endothelial cell proliferation; regulation of inflammatory response; activation of protein kinase activity; endothelial cell migration; negative regulation of transcription, DNA-dependent; embryo implantation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with CALCA purified protein
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000