NP_653300.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,609 Da
NCBI Official Full Name
sodium/potassium-transporting ATPase subunit alpha-4 isoform 1
NCBI Official Synonym Full Names
ATPase Na+/K+ transporting subunit alpha 4
NCBI Protein Information
sodium/potassium-transporting ATPase subunit alpha-4
UniProt Protein Name
Sodium/potassium-transporting ATPase subunit alpha-4
UniProt Synonym Protein Names
Sodium pump subunit alpha-4
UniProt Synonym Gene Names
NCBI Summary for ATP1A4
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for ATP1A4
ATP1A4: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.6.3.9; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 1q23.2
Cellular Component: integral component of plasma membrane; plasma membrane; sodium:potassium-exchanging ATPase complex
Molecular Function: ATP binding; metal ion binding; sodium:potassium-exchanging ATPase activity
Biological Process: ATP hydrolysis coupled proton transport; establishment or maintenance of transmembrane electrochemical gradient; fertilization; potassium ion transport; regulation of cellular pH; regulation of membrane potential; sodium ion transport; sperm motility; spermatogenesis
Research Articles on ATP1A4
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Products associated with ATP1A4 elisa kit
Pathways associated with ATP1A4 elisa kit
Diseases associated with ATP1A4 elisa kit
Organs/Tissues associated with ATP1A4 elisa kit
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