NP_055793.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
135,755 Da
NCBI Official Full Name
VPS10 domain-containing receptor SorCS3
NCBI Official Synonym Full Names
sortilin related VPS10 domain containing receptor 3
NCBI Official Synonym Symbols
NCBI Protein Information
VPS10 domain-containing receptor SorCS3
UniProt Protein Name
VPS10 domain-containing receptor SorCS3
UniProt Synonym Gene Names
UniProt Entry Name
SORC3_HUMAN
NCBI Summary for SORCS3
This gene encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this domain has a consensus motif for proprotein convertase processing, and the C-terminal segment of this domain is characterized by ten conserved cysteine residues. The vacuolar protein sorting 10 domain is followed by a leucine-rich segment, a transmembrane domain, and a short C-terminal cytoplasmic domain that interacts with adaptor molecules. The transcript is expressed at high levels in the brain, and candidate gene studies suggest that genetic variation in this gene is associated with Alzheimer's disease. Consistent with this observation, knockdown of the gene in cell culture results in an increase in amyloid precursor protein processing. [provided by RefSeq, Dec 2014]
UniProt Comments for SORCS3
SORCS3: one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. [provided by RefSeq, Jul 2008]
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 10q23-q25
Cellular Component: integral to membrane; membrane
Molecular Function: neuropeptide receptor activity
Biological Process: learning; memory; neuropeptide signaling pathway
Research Articles on SORCS3
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Products associated with SORCS3 elisa kit
Diseases associated with SORCS3 elisa kit
Organs/Tissues associated with SORCS3 elisa kit
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