NP_001268229.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,517 Da
NCBI Official Full Name
arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform c
NCBI Official Synonym Full Names
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
NCBI Official Synonym Symbols
CRAG; AGAP-3; CENTG3; MRIP-1; cnt-g3 [Similar Products]
NCBI Protein Information
arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3; centaurin-gamma-3; centaurin, gamma 3; CRAM-associated GTPase; MR1-interacting protein; CRMP (collapsin response mediator protein) associated
UniProt Protein Name
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3
UniProt Synonym Protein Names
CRAM-associated GTPase; CRAG; Centaurin-gamma-3; Cnt-g3; MR1-interacting protein; MRIP-1
UniProt Synonym Gene Names
UniProt Entry Name
AGAP3_HUMAN
UniProt Comments for AGAP3
CENTG3: a member of the centaurin family of ADP-ribosylation factor directed (ARF) GTPase-activating proteins (GAPs). Protective against the pathogenesis of polyglutamine diseases. Mediates the nuclear translocation of the CENTG3-polyQ complexes and the formation of promyelocytic leukemia (PML) protein-associated nuclear bodies in reactive oxygen species (ROS) signaling. Promotes the degradation of polyQ proteins at PML nuclear bodies through the ubiquitin-proteasome pathway. Knockdown by small interfering RNA in neuronal cells consistently blocked the nuclear translocation of polyQ and enhanced polyQ-mediated cell death. Three alternatively-spliced isoforms have been described.
Protein type: GAPs, ARF; GAPs
Chromosomal Location of Human Ortholog: 7q36.1
Cellular Component: membrane; cytoplasm; nucleus
Molecular Function: GTPase activity; GTP binding; zinc ion binding; polyubiquitin binding
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein import into nucleus, translocation; small GTPase mediated signal transduction; positive regulation of GTPase activity
Research Articles on AGAP3
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Pathways associated with AGAP3 elisa kit
Diseases associated with AGAP3 elisa kit
Organs/Tissues associated with AGAP3 elisa kit
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