Q9NZU7.5
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
8,139 Da
NCBI Official Full Name
Calcium-binding protein 1
NCBI Official Synonym Full Names
calcium binding protein 1
NCBI Protein Information
calcium-binding protein 1; caldendrin; calcium binding protein 5
UniProt Protein Name
Calcium-binding protein 1
UniProt Synonym Protein Names
Calbrain; Caldendrin
UniProt Synonym Gene Names
UniProt Entry Name
CABP1_HUMAN
NCBI Summary for CABP1
Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results in multiple transcript variants encoding disinct isoforms. [provided by RefSeq, Jul 2012]
UniProt Comments for CABP1
CABP1: Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhibits TRPC5 channels. Prevents NMDA receptor- induced cellular degeneration. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Calcium-binding; Adaptor/scaffold; Inhibitor
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component: extracellular space; internal side of plasma membrane; protein complex; postsynaptic density; dendrite; cell cortex; cytosol; Golgi membrane; postsynaptic membrane; cytoskeleton; cell soma; perinuclear region of cytoplasm; plasma membrane; cell junction; nucleus
Molecular Function: enzyme inhibitor activity; protein domain specific binding; protein binding; protein homodimerization activity; nuclear localization sequence binding; type 3 metabotropic glutamate receptor binding; calcium ion binding; calcium-dependent protein binding
Biological Process: negative regulation of catalytic activity; negative regulation of protein import into nucleus
Research Articles on CABP1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with CABP1 elisa kit
Diseases associated with CABP1 elisa kit
Organs/Tissues associated with CABP1 elisa kit
|