NP_004372.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
76,412 Da
NCBI Official Full Name
cyclic AMP-dependent transcription factor ATF-6 beta isoform a
NCBI Official Synonym Full Names
activating transcription factor 6 beta
NCBI Protein Information
cyclic AMP-dependent transcription factor ATF-6 beta; protein G13; Creb-related protein; cAMP responsive element binding protein-like 1; cAMP-dependent transcription factor ATF-6 beta; cAMP-responsive element-binding protein-like 1; cAMP response element-binding protein-related protein
UniProt Protein Name
Cyclic AMP-dependent transcription factor ATF-6 beta
UniProt Synonym Protein Names
Activating transcription factor 6 beta; ATF6-beta; Protein G13; cAMP response element-binding protein-related protein; Creb-rp; cAMP-responsive element-binding protein-like 1Cleaved into the following chain:Processed cyclic AMP-dependent transcription factor ATF-6 beta
UniProt Synonym Gene Names
CREBL1; G13; cAMP-dependent transcription factor ATF-6 beta; ATF6-beta; Creb-rp [Similar Products]
UniProt Entry Name
ATF6B_HUMAN
NCBI Summary for ATF6B
The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
UniProt Comments for ATF6B
ATF6B: Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE. Belongs to the bZIP family. ATF subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Transcription factor
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; intracellular; nucleus
Molecular Function: protein binding; sequence-specific DNA binding; transcription factor activity
Biological Process: transcription, DNA-dependent; unfolded protein response; signal transduction
Research Articles on ATF6B
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Pathways associated with ATF6B elisa kit
Diseases associated with ATF6B elisa kit
Organs/Tissues associated with ATF6B elisa kit
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