NP_001122397.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,805 Da
NCBI Official Full Name
cytochrome P450 2C18 isoform 2
NCBI Official Synonym Full Names
cytochrome P450, family 2, subfamily C, polypeptide 18
NCBI Official Synonym Symbols
CPCI; CYP2C; CYP2C17; P450IIC17; P450-6B/29C [Similar Products]
NCBI Protein Information
cytochrome P450 2C18; CYPIIC18; cytochrome P450-6B/29C; microsomal monooxygenase; unspecific monooxygenase; flavoprotein-linked monooxygenase; (S)-mephenytoin hydroxylase associated cytochrome P450; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18
UniProt Protein Name
Cytochrome P450 2C18
UniProt Synonym Protein Names
CYPIIC18; Cytochrome P450-6b/29c
UniProt Entry Name
CP2CI_HUMAN
NCBI Summary for CYP2C18
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CYP2C18
CYP2C18: a member of the cytochrome P450 superfamily of enzymes. Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. Participates in the oxidation of a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.
Protein type: EC 1.14.14.1; Xenobiotic Metabolism - metabolism by cytochrome P450; Oxidoreductase; Lipid Metabolism - linoleic acid; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Lipid Metabolism - arachidonic acid; Cofactor and Vitamin Metabolism - retinol
Chromosomal Location of Human Ortholog: 10q24
Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; cytoplasm
Molecular Function: iron ion binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; arachidonic acid epoxygenase activity; steroid hydroxylase activity; oxygen binding; monooxygenase activity
Biological Process: xenobiotic metabolic process; exogenous drug catabolic process; epoxygenase P450 pathway
Research Articles on CYP2C18
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Products associated with CYP2C18 elisa kit
Pathways associated with CYP2C18 elisa kit
Diseases associated with CYP2C18 elisa kit
Organs/Tissues associated with CYP2C18 elisa kit
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