NP_446107.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
80,104 Da
NCBI Official Full Name
dynamin-1-like protein
NCBI Official Synonym Full Names
dynamin 1-like
NCBI Protein Information
dynamin-1-like protein
UniProt Protein Name
Dynamin-1-like protein
UniProt Synonym Protein Names
Dynamin-like protein
UniProt Synonym Gene Names
UniProt Entry Name
DNM1L_RAT
NCBI Summary for DNM1L
human homolog is a GTPase that is necessary for peroxisome division [RGD, Feb 2006]
UniProt Comments for DNM1L
DRP1: Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into ring-like structures which wrap around the scission site to constict and sever the mitochondrial membrane through a GTP hydrolysis- dependent mechanism. Required for normal brain development. Facilitates developmentally-regulated apoptosis during neural tube development. Required for a normal rate of cytochrome c release and caspase activation during apoptosis. Also required for mitochondrial fission during mitosis. May be involved in vesicle transport. Homotetramer; dimerizes through the N-terminal GTP-middle region of one molecule binding to the GED domain of another DNM1L molecule. Can self-assemble in multimeric ring-like structures. Interacts with BCL2L1; the interaction stimulates the GTPase activity of DMN1L in synapses and increases the number of axonal mitochondria and the size and number of synaptic vesicle clusters. Interacts with FIS1. Interacts with GSK3B and MARCH5. Interacts (via the GTPase and B domains) with UBE2I; the interaction promotes sumoylation of DNM1L, mainly in ite B domain. Interacts with PPP3CA; the interaction dephosphorylates DNM1L and regulates its transition to mitochondria. Interacts witn MID49 and MID51. Ubiquitously expressed with highest levels found in skeletal muscles, heart, kidney and brain. Isoform 1 is brain-specific. Isoform 2 and isoform 3 are predominantly expressed in testis and skeletal muscles respectively. Isoform 4 is weakly expressed in brain, heart and kidney. Isoform 5 is dominantly expressed in liver, heart and kidney. Isoform 6 is expressed in neurons. Belongs to the dynamin family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Microtubule-binding; Endoplasmic reticulum; Motor; Hydrolase; EC 3.6.5.5; Mitochondrial; Apoptosis
Cellular Component: brush border; cell junction; coated pit; cytoplasm; cytosol; Golgi apparatus; intracellular membrane-bound organelle; membrane; microtubule; microtubule cytoskeleton; mitochondrial outer membrane; mitochondrion; perinuclear region of cytoplasm; peroxisome; protein complex; synaptic vesicle membrane
Molecular Function: GTP binding; GTPase activity; identical protein binding; lipid binding; protein binding; protein homodimerization activity; ubiquitin protein ligase binding
Biological Process: endocytosis; heart contraction; mitochondrial fission; mitochondrial fragmentation during apoptosis; peroxisome fission; positive regulation of apoptosis; positive regulation of protein secretion; protein homotetramerization; regulation of protein oligomerization; release of cytochrome c from mitochondria
Research Articles on DNM1L
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Products associated with DNM1L elisa kit
Pathways associated with DNM1L elisa kit
Diseases associated with DNM1L elisa kit
Organs/Tissues associated with DNM1L elisa kit
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