NP_001351834.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
317,702 Da
NCBI Official Full Name
lipopolysaccharide-responsive and beige-like anchor protein isoform 3
NCBI Official Synonym Full Names
LPS responsive beige-like anchor protein
NCBI Protein Information
lipopolysaccharide-responsive and beige-like anchor protein
UniProt Protein Name
Lipopolysaccharide-responsive and beige-like anchor protein
UniProt Synonym Protein Names
Beige-like protein; CDC4-like protein
UniProt Synonym Gene Names
NCBI Summary for LRBA
The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
UniProt Comments for LRBA
May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules.
Research Articles on LRBA
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