NP_958849.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,058 Da
NCBI Official Full Name
transcriptional enhancer factor TEF-3 isoform 2
NCBI Official Synonym Full Names
TEA domain family member 4
NCBI Official Synonym Symbols
TEF3; RTEF1; TEF-3; EFTR-2; TEFR-1; TCF13L1; hRTEF-1B [Similar Products]
NCBI Protein Information
transcriptional enhancer factor TEF-3; transcription factor RTEF-1; transcription factor 13-like 1; transcriptional enhancer factor 3; related transcription enhancer factor 1B; transcriptional enhancer factor 1-related
UniProt Protein Name
Transcriptional enhancer factor TEF-3
UniProt Synonym Protein Names
TEA domain family member 4; TEAD-4; Transcription factor 13-like 1; Transcription factor RTEF-1
UniProt Synonym Gene Names
UniProt Entry Name
TEAD4_HUMAN
NCBI Summary for TEAD4
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for TEAD4
TEAD4: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 12p13.3-p13.2
Cellular Component: nucleoplasm
Molecular Function: protein binding; DNA binding; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; muscle development; gene expression; skeletal development
Research Articles on TEAD4
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Products associated with TEAD4 elisa kit
Pathways associated with TEAD4 elisa kit
Diseases associated with TEAD4 elisa kit
Organs/Tissues associated with TEAD4 elisa kit
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