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CAPN3 cdna clone

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Catalog # MBS1266191
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
CAPN3 cdna clone
Product Name

CAPN3, cDNA Clone

Popular Item
Full Product Name

CAPN3 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
atgcacggga acaagcagca cctgcagaag gacttcttcc tgtacaacgc ctccaaggcc aggagcaaaa cctacatcaa catgcgggag gtgtcccagc gcttccgcct gcctcccagc gagtacgtca tcgtgccctc cacctacgag ccccaccagg agggggaatt catcctccgg gtcttctctg aaaagaggaa cctctctgag gaagttgaaa ataccatctc cgtggatcgg ccagtgaaaa agaaaaaaac caagcccatc atcttcgttt cggacagagc aaacagcaac aaggagctgg gtgtggacca ggagtcagag gagggcaaag gcaaaacaag ccctgataag caaaagcagt ccccacagcc acagcctggc agctctgatc aggaaagtga ggaacagcaa caattccgga acattttcaa gcagatagca ggagatgaca tggagatctg tgcagatgag ctcaagaagg tccttaacac agtcgtgaac aaacacaagg acctgaagac acacgggttc acactggagt cctgccgtag catgattgcg ctcatggata cagatggctc tggaaagctc aacctgcagg agttccacca cctctggaac aagattaagg cctggcagaa aattttcaaa cactatgaca cagaccagtc cggcaccatc aacagctacg agatgcgaaa tgcagtcaac gacgcaggat tccacctcaa caaccagctc tatgacatca ttaccatgcg gtacgcagac aaacacatga acatcgactt tgacagtttc atctgctgct tcgttaggct ggagggcatg ttcagagctt ttcatgcatt tgacaaggat ggagatggta tcatcaagct caacgttctg gagtggctgc agctcaccat gtatgcctga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of CAPN3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CAPN3. It may not necessarily be applicable to this product.
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
18,246 Da
NCBI Official Full Name
Homo sapiens calpain 3, (p94), mRNA
NCBI Official Synonym Full Names
calpain 3
NCBI Official Symbol
CAPN3  [Similar Products]
NCBI Official Synonym Symbols
p94; CANP3; LGMD2; nCL-1; CANPL3; LGMD2A
  [Similar Products]
NCBI Protein Information
UniProt Protein Name
UniProt Synonym Protein Names
Calcium-activated neutral proteinase 3; CANP 3; Calpain L3; Calpain p94; Muscle-specific calcium-activated neutral protease 3; New calpain 1; nCL-1
Protein Family
UniProt Gene Name
CAPN3  [Similar Products]
UniProt Synonym Gene Names
CANP3; CANPL3; NCL1; CANP 3; nCL-1  [Similar Products]
UniProt Entry Name
NCBI Summary for CAPN3
Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. [provided by RefSeq, Jul 2008]
UniProt Comments for CAPN3
CAPN3: Calcium-regulated non-lysosomal thiol-protease. Defects in CAPN3 are the cause of limb-girdle muscular dystrophy type 2A (LGMD2A). LGMD2A is an autosomal recessive degenerative myopathy characterized by progressive symmetrical atrophy and weakness of the proximal limb muscles and elevated serum creatine kinase. The symptoms usually begin during the first two decades of life, and the disease gradually worsens, often resulting in loss of walking ability 10 or 20 years after onset. Belongs to the peptidase C2 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Motility/polarity/chemotaxis; Cell development/differentiation; EC; Calcium-binding

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: cytoplasm; cytosol; intracellular; myofibril; nucleus; plasma membrane; protein complex; T-tubule; Z disc

Molecular Function: calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; catalytic activity; cysteine-type peptidase activity; ligase regulator activity; peptidase activity; protein binding; protein complex scaffold; signal transducer activity; sodium ion binding; structural constituent of muscle; titin binding

Biological Process: activation of NF-kappaB transcription factor; apoptosis; muscle development; muscle maintenance; myofibril assembly; negative regulation of apoptosis; negative regulation of protein sumoylation; negative regulation of transcription, DNA-dependent; positive regulation of proteolysis; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of satellite cell activation involved in skeletal muscle regeneration; positive regulation of transcription, DNA-dependent; protein complex assembly; proteolysis; regulation of catalytic activity; regulation of I-kappaB kinase/NF-kappaB cascade; response to calcium ion; response to muscle activity; sarcomere organization

Disease: Muscular Dystrophy, Limb-girdle, Type 2a
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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