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Capn6 recombinant protein :: Calpain-6 (Capn6) Recombinant Protein

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Catalog # MBS1003842
Unit / Price
Scan QR to view Datasheet
  0.05 mg (E-Coli)  /  $1,065 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $1,095 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,330 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,440 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,495 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,575 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,590 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,690 +2 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,930 +2 FREE 8GB USB
  1 mg (E-Coli)  /  $2,410 +3 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,490 +3 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,515 +3 FREE 8GB USB
  1 mg (Yeast)  /  $2,665 +3 FREE 8GB USB
  1 mg (Baculovirus)  /  $3,830 +4 FREE 8GB USB
Capn6 recombinant protein
Product Name

Calpain-6 (Capn6), Recombinant Protein

Full Product Name

Recombinant Rat Calpain-6 (Capn6)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-641aa, Full length protein
Sequence
MGPPLKLFKN QKYQELKQDC MKDGRLFCDP TFLPENDSLF FNRLLPGKVV WKRPQDISDD PHLIVGNISN HQLIQGRLGN KAMISAFSCL AVQESHWTKA IPNHKEQEWD PRKPEKYAGI FRFRFWHFGE WTEVVIDDLL PTINGDLVFS FSTSMNEFWN ALLEKAYAKL LGCYEALDGL TITDIIMDFT GTLAEIIDMQ KGRYTDLVEE KYKLFGELYK TFTKGGLISC SIESPSQEEQ EVETDWGLLK GYTYTMTDIR KLRLGERLVE VFSTEKLYMV RLRNPLGRQE WSGPWSEISE EWQQLTVTDR KNLGLVMSDD GEFWMSLEDF CHNFHKLNVC RNVNNPVFGR KELESVVGCW TVDDDPLMNR SGGCYNNRDT FLQNPQYIFT VPEDGHKVIM SLQQKDLRTY RRMGRPDNYI IGFELFKVEM NRRFRLHHLY IQERAGTSTY IDTRTVFLSK YLKKGNYVLV PTMFQHGRTS EFLLRIFSEV PVQLRELTLD MPKMSCWNLA RGYPKVVTQI TVHSAEGLEK KYANETVNPY LTIKCGKEEV RSPVQKNTVH AIFDTQAIFY RRTTDIPIII QVWNSRKFCD QFLGQVTLDA DPSDCRDLKS LYLRKKGGPT AKVKQGHISF KVISSDDLTE L
3D Structure
ModBase 3D Structure for O88501
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Rat
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Capn6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Capn6 recombinant protein
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. This protein is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis.
NCBI/Uniprot data below describe general gene information for Capn6. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
74,560 Da
NCBI Official Full Name
calpain-6
NCBI Official Synonym Full Names
calpain 6
NCBI Official Symbol
Capn6  [Similar Products]
NCBI Protein Information
calpain-6
UniProt Protein Name
Calpain-6
Protein Family
UniProt Gene Name
Capn6  [Similar Products]
UniProt Synonym Gene Names
Capa6  [Similar Products]
NCBI Summary for Capn6
human and mouse homologs lack the calmodulin-like domain present in other members of the calpain family of calcium-dependent, cysteine proteases and may be proteolytically inactive [RGD, Feb 2006]
UniProt Comments for Capn6
Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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