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CASP1 recombinant protein :: Caspase-1 (CASP1) Recombinant Protein

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Catalog # MBS1390670
Unit / Price
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  0.05 mg (E-Coli)  /  $575 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $710 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $770 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $850 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $950 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $965 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,090 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,185 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,275 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,360 +1 FREE 8GB USB
  1 mg (Yeast)  /  $1,725 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $1,780 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $1,930 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,775 +3 FREE 8GB USB
CASP1 recombinant protein
Product Name

Caspase-1 (CASP1), Recombinant Protein

Full Product Name

Recombinant Pig Caspase-1 (CASP1)

Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
120-297aa, Full Length of Mature Protein
Sequence
NPVKPASSEP RGSLKLCPPD IAQRLWKEKS AEIYPIMGKS IRTRLALIIC NTEFENLPRR DGADVDIRDM KILLEDLGYS VDVRENLTAS DMAIELKAFA ARPEHKSSDS TFLVLMSHGI QAGICGKKYS EEVPDVLEVN TVFQILNTLN CPSLKDKPKV IIIQACRGEK QGVVWIKD
3D Structure
ModBase 3D Structure for Q9N2I1
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Sus scrofa (Pig)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CASP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CASP1 recombinant protein
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms.
NCBI/Uniprot data below describe general gene information for CASP1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
44,882 Da
NCBI Official Full Name
caspase-1
NCBI Official Symbol
CASP1  [Similar Products]
NCBI Protein Information
caspase-1
UniProt Protein Name
Caspase-1
UniProt Synonym Protein Names
Interleukin-1 beta convertase; IL-1BC
UniProt Gene Name
CASP1  [Similar Products]
UniProt Synonym Gene Names
IL1BC; CASP-1; IL-1BC; ICE; IL-1 beta-converting enzyme  [Similar Products]
UniProt Comments for CASP1
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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