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CASP3 recombinant protein :: Caspase-3 (CASP3) Recombinant Protein

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Catalog # MBS1399898
Unit / Price
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  0.05 mg (E-Coli)  /  $545 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $685 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $725 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $800 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $920 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $930 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,050 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,155 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,195 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,320 +1 FREE 8GB USB
  1 mg (Yeast)  /  $1,665 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $1,735 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $1,890 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,700 +3 FREE 8GB USB
CASP3 recombinant protein
Product Name

Caspase-3 (CASP3), Recombinant Protein

Full Product Name

Recombinant Bovine Caspase-3 (CASP3)

Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
29-175aa, Full Length of Mature Protein
Sequence
SGISLEESYK MDYPEMGLCI IINNKNFHEN TGMACRSGTD VDAANLRETF MNLKYEVRIK NDLTCKEMLE LMSNVSKEDH SKRSSFICVL LSHGEEGIIF GTNGPVNLKK LASFFRGDYC RSLTGKPKLF IIQACRGTEL DCGIETD
3D Structure
ModBase 3D Structure for Q08DY9
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Bovine
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CASP3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CASP3 recombinant protein
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer s disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
NCBI/Uniprot data below describe general gene information for CASP3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
31,136 Da
NCBI Official Full Name
caspase-3
NCBI Official Synonym Full Names
caspase 3
NCBI Official Symbol
CASP3  [Similar Products]
NCBI Protein Information
caspase-3
UniProt Protein Name
Caspase-3
Protein Family
UniProt Gene Name
CASP3  [Similar Products]
UniProt Synonym Gene Names
CASP-3  [Similar Products]
UniProt Comments for CASP3
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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