NP_001303597.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
126,746 Da
NCBI Official Full Name
rho GTPase-activating protein 7 isoform 5
NCBI Official Synonym Full Names
DLC1 Rho GTPase activating protein
NCBI Official Synonym Symbols
HP; ARHGAP7; STARD12; p122-RhoGAP [Similar Products]
NCBI Protein Information
rho GTPase-activating protein 7
UniProt Protein Name
Rho GTPase-activating protein 7
UniProt Synonym Protein Names
Deleted in liver cancer 1 protein; DLC-1; HP protein; Rho-type GTPase-activating protein 7; START domain-containing protein 12; StARD12; StAR-related lipid transfer protein 12
UniProt Synonym Gene Names
UniProt Entry Name
RHG07_HUMAN
NCBI Summary for DLC1
This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]
UniProt Comments for DLC1
Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.
Research Articles on DLC1
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Products associated with DLC1 elisa kit
Pathways associated with DLC1 elisa kit
Diseases associated with DLC1 elisa kit
Organs/Tissues associated with DLC1 elisa kit
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