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CATSPER1 elisa kit :: Canine Cation channel sperm-associated protein 1 (CATSPER1) ELISA Kit

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Catalog # MBS7227858
Unit / Price
  48-Strip-Wells  /  $440 +1 FREE 8GB USB
  96-Strip-Wells  /  $640 +1 FREE 8GB USB
  5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
  10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
CATSPER1 elisa kit
Product Name

Cation channel sperm-associated protein 1 (CATSPER1), ELISA Kit

Also Known As

Canine Cation channel sperm-associated protein 1 (CATSPER1) ELISA Kit

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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OMIM
gene 612997
Species Reactivity
Samples
Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
Preparation and Storage
Store all reagents at 2-8 degree C.
Sample Preparation
We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of CATSPER1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms forCATSPER1purchase
MBS7227858 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cation channel sperm-associated protein 1 (CATSPER1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CATSPER1. The ELISA analytical biochemical technique of the MBS7227858 kit is based on CATSPER1 antibody-CATSPER1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CATSPER1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CATSPER1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Product Categories/Family for CATSPER1 elisa kit
NCBI/Uniprot data below describe general gene information for CATSPER1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
90,091 Da
NCBI Official Full Name
cation channel sperm-associated protein 1
NCBI Official Synonym Full Names
cation channel, sperm associated 1
NCBI Official Symbol
CATSPER1  [Similar Products]
NCBI Official Synonym Symbols
SPGF7; CATSPER
  [Similar Products]
NCBI Protein Information
cation channel sperm-associated protein 1; hCatSper; sperm ion channel; sperm-associated cation channel 1
UniProt Protein Name
Cation channel sperm-associated protein 1
UniProt Gene Name
CATSPER1  [Similar Products]
UniProt Synonym Gene Names
CatSper1; hCatSper  [Similar Products]
UniProt Entry Name
CTSR1_HUMAN
NCBI Summary for CATSPER1
Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. [provided by RefSeq, Jul 2008]
UniProt Comments for CATSPER1
CATSPER1: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. Defects in CATSPER1 are the cause of spermatogenic failure type 7 (SPGF7). An infertility disorder characterized by non-motile sperm or sperm motility below the normal threshold, low sperm count, increased abnormally structured spermatozoa, and reduced semen volume. Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: plasma membrane

Molecular Function: voltage-gated calcium channel activity; protein binding; calcium activated cation channel activity

Biological Process: sperm-egg recognition; sperm motility; fusion of sperm to egg plasma membrane; single fertilization; multicellular organismal development; spermatogenesis; regulation of calcium ion transport; cell differentiation; multicellular organism reproduction

Disease: Spermatogenic Failure 7
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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