NP_001229993.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
caveolin-1 isoform 2
NCBI Official Synonym Full Names
caveolin 1, caveolae protein
NCBI Official Synonym Symbols
NCBI Protein Information
caveolin-1
UniProt Protein Name
Caveolin-1
UniProt Synonym Gene Names
UniProt Comments for CAV1
Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation (). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (PubMed:10816572). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19546242).
Product References and Citations for anti-CAV1 antibody
1. Scherer P.E., Tang Z., et al. J. Biol. Chem. 270:16395-16401(1995). 2. Okamoto, T., et al. Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane. J. Biol. Chem. 273: 5419-5422 (1998). 3. Smart, E.J., et al. Caveolins, liquid-ordered domains, and signal transduction. Mol. Cell. Biol. 19: 7289-7304(1999).
Research Articles on CAV1
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Pathways associated with anti-CAV1 antibody
Diseases associated with anti-CAV1 antibody
Organs/Tissues associated with anti-CAV1 antibody
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