NP_001746.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
core-binding factor subunit beta isoform 2
NCBI Official Synonym Full Names
core-binding factor subunit beta
NCBI Official Synonym Symbols
NCBI Protein Information
core-binding factor subunit beta
UniProt Protein Name
Core-binding factor subunit beta
UniProt Synonym Protein Names
Polyomavirus enhancer-binding protein 2 beta subunit; PEA2-beta; PEBP2-beta; SL3-3 enhancer factor 1 subunit beta; SL3/AKV core-binding factor beta subunit
UniProt Synonym Gene Names
NCBI Summary for CBF beta
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CBF beta
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBFB enhances DNA binding by RUNX1.
Research Articles on CBF beta
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-CBF beta antibody
Pathways associated with anti-CBF beta antibody
Diseases associated with anti-CBF beta antibody
Disease Name |
Pubmed Publications |
Neoplasms Antibodies |
>165 publications with CBF beta and Neoplasms |
Leukemia, Myeloid, Acute Antibodies |
>148 publications with CBF beta and Leukemia, Myeloid, Acute |
Leukemia, Myelomonocytic, Acute Antibodies |
>29 publications with CBF beta and Leukemia, Myelomonocytic, Acute |
Musculoskeletal Diseases Antibodies |
>6 publications with CBF beta and Musculoskeletal Diseases |
Disease Models, Animal Antibodies |
>5 publications with CBF beta and Disease Models, Animal |
Hemorrhage Antibodies |
>5 publications with CBF beta and Hemorrhage |
Bone Diseases, Developmental Antibodies |
>4 publications with CBF beta and Bone Diseases, Developmental |
Cardiovascular Diseases Antibodies |
>2 publications with CBF beta and Cardiovascular Diseases |
Precancerous Conditions Antibodies |
>1 publications with CBF beta and Precancerous Conditions |
Abnormalities, Drug-Induced Antibodies |
>1 publications with CBF beta and Abnormalities, Drug-Induced |
Organs/Tissues associated with anti-CBF beta antibody
|