NP_060191.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
103,934 Da
NCBI Official Full Name
coiled-coil and C2 domain-containing protein 1A
NCBI Official Synonym Full Names
coiled-coil and C2 domain containing 1A
NCBI Protein Information
coiled-coil and C2 domain-containing protein 1A
UniProt Protein Name
Coiled-coil and C2 domain-containing protein 1A
UniProt Synonym Protein Names
Akt kinase-interacting protein 1; Five prime repressor element under dual repression-binding protein 1; FRE under dual repression-binding protein 1; Freud-1; Putative NF-kappa-B-activating protein 023N
UniProt Synonym Gene Names
NCBI Summary for CC2D1A
This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in a nonsyndromic form of cognitive disability (MRT3). [provided by RefSeq, Jul 2017]
UniProt Comments for CC2D1A
Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis.
Research Articles on CC2D1A
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Products associated with CC2D1A rtu elisa kit
Pathways associated with CC2D1A rtu elisa kit
Diseases associated with CC2D1A rtu elisa kit
Organs/Tissues associated with CC2D1A rtu elisa kit
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