BAA04759.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,419 Da
NCBI Official Full Name
cholecystokinin-B receptor/gastrin receptor
NCBI Official Synonym Full Names
cholecystokinin B receptor
NCBI Protein Information
gastrin/cholecystokinin type B receptor; CCK-BR; CCK2-R; CCK2 receptor; CCK-B receptor; gastrin receptor; cholecystokinin-2 receptor
UniProt Protein Name
Gastrin/cholecystokinin type B receptor
UniProt Synonym Protein Names
Cholecystokinin-2 receptor
UniProt Synonym Gene Names
UniProt Entry Name
GASR_HUMAN
NCBI Summary for CCKBR
This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Jul 2008]
UniProt Comments for CCKBR
CCKBR: Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11p15.4
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: type B gastrin/cholecystokinin receptor binding; protein binding; gastrin receptor activity; 1-phosphatidylinositol-3-kinase regulator activity; cholecystokinin receptor activity; phosphoinositide phospholipase C activity
Biological Process: gastric acid secretion; gland development; cell proliferation; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; gut development; metabolic process; sensory perception; digestion; positive regulation of cell proliferation; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); feeding behavior; regulation of phosphoinositide 3-kinase activity
Research Articles on CCKBR
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Products associated with CCKBR elisa kit
Pathways associated with CCKBR elisa kit
Diseases associated with CCKBR elisa kit
Organs/Tissues associated with CCKBR elisa kit
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