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CCR5 recombinant protein :: C-C chemokine receptor type 5 (CCR5) Recombinant Protein

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Catalog # MBS1233558
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CCR5 recombinant protein
Product Name

C-C chemokine receptor type 5 (CCR5), Recombinant Protein

Full Product Name

Recombinant Pan troglodytes C-C chemokine receptor type 5 (CCR5)

Product Synonym Names
Recombinant C-C chemokine receptor type 5 (CCR5); C-C chemokine receptor type 5; C-C CKR-5; CC-CKR-5; CCR-5; CCR5; CD_antigen= CD195
Product Synonym Gene Name
CCR5; CMKBR5[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
302-352, Fragment at the C-terminal, provide the last intracellular
Sequence
EKFRNYLLVF FQKHIAKRFC KCCSIFQQEA PERASSVYTR STGEQEISVG L
Chromosome Location
Chromosome: 3; NC_006490.3 (47071612..47072670). Location: chromosome: 3
3D Structure
ModBase 3D Structure for P56440
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Pan troglodytes (Chimpanzee)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CCR5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CCR5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,539 Da[Similar Products]
NCBI Official Full Name
C-C chemokine receptor type 5
NCBI Official Symbol
NCBI Protein Information
C-C chemokine receptor type 5; CCR-5; CC-CKR-5; C-C CKR-5
UniProt Protein Name
C-C chemokine receptor type 5
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
CMKBR5; C-C CKR-5; CC-CKR-5; CCR-5; CCR5  [Similar Products]
UniProt Entry Name
CCR5_PANTR
UniProt Comments for CCR5
Function: Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation

By similarity.

Subunit structure: Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2

By similarity.

Subcellular location: Cell membrane; Multi-pass membrane protein.

Post-translational modification: Sulfated on at least 2 of the N-terminal tyrosines. Sulfation is required for efficient binding of the chemokines, CCL3 and CCL4

By similarity.O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen

By similarity.Palmitoylation in the C-terminal is important for cell surface expression

By similarity.Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES

By similarity.

Sequence similarities: Belongs to the G-protein coupled receptor 1 family.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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