BC069678
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,713 Da
NCBI Official Full Name
Homo sapiens chemokine (C-C motif) receptor 9, mRNA
NCBI Official Synonym Full Names
C-C motif chemokine receptor 9
NCBI Official Synonym Symbols
GPR28; CDw199; GPR-9-6; CC-CKR-9 [Similar Products]
NCBI Protein Information
C-C chemokine receptor type 9
UniProt Protein Name
C-C chemokine receptor type 9
UniProt Synonym Protein Names
G-protein coupled receptor 28; GPR-9-6; CD_antigen: CDw199
UniProt Synonym Gene Names
UniProt Entry Name
CCR9_HUMAN
NCBI Summary for CCR9
The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Comments for CCR9
CCR9: Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, GPCR
Chromosomal Location of Human Ortholog: 3p21.3
Cellular Component: cell surface; integral to plasma membrane; plasma membrane
Molecular Function: chemokine receptor activity
Biological Process: cellular defense response; elevation of cytosolic calcium ion concentration
Research Articles on CCR9
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Pathways associated with CCR9 cdna clone
Diseases associated with CCR9 cdna clone
Organs/Tissues associated with CCR9 cdna clone
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