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CD126 recombinant protein :: IL-6 Receptor (IL-6R) Recombinant Protein

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Catalog # MBS553305
Unit / Price
  0.01 mg  /  $220 +1 FREE 8GB USB
  0.05 mg  /  $540 +1 FREE 8GB USB
  0.5 mg  /  $2,835 +3 FREE 8GB USB
CD126 recombinant protein
Product Name

IL-6 Receptor (IL-6R) (CD126), Recombinant Protein

Popular Item
Also Known As

Mouse IL-6 Receptor Recombinant (IL-6R)

Product Synonym Names
Mouse CD126 Recombinant (IL6 Receptor) ; cd-126 IL6R; CD126; IL-6R-1; IL-6R-alpha; IL6RA; MGC104991; IL6 Receptor
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS553305 COA
Sequence Length
460
3D Structure
ModBase 3D Structure for P22272
Purity/Purification
>97%, as determined by SDS-PAGE
Form/Format
Recombinant Mouse Interleukin-6 receptor (CD126) is supplied as a 0.2 um filtered PBS solution, pH7.2.
Host Note
Optimized DNA sequence encoding extracellular domain of mouse IL-6 receptor (CD126) including a C-terminal 6His tag was expressed in HEK293 cells.
Molecular Weight
Recombinant mouse IL-6 (CD126) is a monomer protein consisting of 357 amino acid residue subunits, due to glycosylation migrates as an approximately 60-65 kDa protein on SDS-PAGE.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL.This solution can then be diluted into other buffers.
Preparation and Storage
Recombinant Mouse IL-6R as supplied can be stored in working aliquots at 2-8°C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of CD126 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CD126 recombinant protein
The effects of IL-6 are mediated by a functional IL- 6 receptor (IL-6R), which consists in a heterodimer formed by an IL-6-binding α chain (IL-6Rα) and a signal- transducing subunit, gp130 or IL-6Rβ. Binding of IL-6 to the IL-6Rα induces homodimerization of two gp130 molecules, leading to intracellular signals.
Product Categories/Family for CD126 recombinant protein
NCBI/Uniprot data below describe general gene information for CD126. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
NCBI Official Full Name
interleukin-6 receptor subunit alpha
UniProt Protein Name
Interleukin-6 receptor subunit alpha
UniProt Synonym Protein Names
IL-6R 1
UniProt Gene Name
Il6ra  [Similar Products]
UniProt Synonym Gene Names
Il6r; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA  [Similar Products]
UniProt Entry Name
IL6RA_MOUSE
UniProt Comments for CD126
IL6R: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Belongs to the type I cytokine receptor family. Type 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Cellular Component: extracellular space; cell surface; membrane; apical plasma membrane; integral to membrane; extracellular region; interleukin-6 receptor complex

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein homodimerization activity; interleukin-6 receptor binding; enzyme binding; interleukin-6 binding; ciliary neurotrophic factor receptor activity; interleukin-6 receptor activity

Biological Process: negative regulation of collagen biosynthetic process; cytokine and chemokine mediated signaling pathway; positive regulation of smooth muscle cell proliferation; positive regulation of interleukin-6 production; positive regulation of JAK-STAT cascade; endocrine pancreas development; positive regulation of chemokine production; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of MAPKKK cascade; response to cytokine stimulus; positive regulation of cell proliferation; cell growth

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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