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CD176 recombinant protein :: Transferrin / CD176 / Serotransferrin Recombinant Protein

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Catalog # MBS2546773
Unit / Price
  0.05 mg  /  $405 +1 FREE 8GB USB
  0.1 mg  /  $635 +1 FREE 8GB USB
SDS-PAGE
Product Name

Transferrin / CD176 / Serotransferrin, Recombinant Protein

Popular Item
Full Product Name

Recombinant Mouse Transferrin / CD176 / Serotransferrin Protein (Fc tag)

Product Synonym Names
TRF, Tf
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS2546773 Technical Datasheet
3D Structure
ModBase 3D Structure for Q921I1
Host
Human Cells
Purity/Purification
> 90 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH7.4, 5% Trehalose, 5% mannitol, 0.01% Tween-80
Predicted N Terminal
Val 20
Endotoxin
< 1.0 EU per ug of the protein as determined by the LAL method
Reconstitution
It is recommended that sterile water (400 ?l) be added to the vial to prepare a stock solution of 0.25 mg/mL. Concentration is measured by UV-Vis.
Preparation and Storage
Store it under sterile conditions at -20 degree C to -80 degree C upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of CD176 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CD176 recombinant protein
Background: Transferrin is a glycoprotein with an approximate molecular weight of 76.5 kDa. This glycoprotein is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of Transferrin is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte / pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. Transferrins are iron binding transport proteins which bind Fe3+ ion in association with the binding of an anion, usually bicarbonate. This transferrin binds only one Fe3+ ion per protein molecule. Transports iron ions from the hemolymph into the eggs during the vitellogenic stage. Transferrins are iron binding transport proteins which can bind two Fe (3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. When a transferrin loaded with iron encounters with a transferring receptor on cell surface, transferring binds to it and, as a consequence, is transported into the cell in a visicle by receptor-mediated endocytosis. The PH is reduced by hydrogen iron pumps. The lower pH causes transferrin to release its iron ions. The receptor is then transported through the endocytic cycle back to the cell surface, ready for another round of iron uptake. Each transferrin molecule has the ability to carry two iron ions in the ferric form.

Description: A DNA sequence encoding the mouse TRF (Q921I1) (Met1-His697) was expressed with the Fc region of human IgG1 at the C-terminus.
Application Notes for CD176 recombinant protein
The recombinant mouse TRF/Fc is a disulfide-linked homodimer. The reduced monomer comprises 919 amino acids and has a predicted molecular mass of 101.9 kDa. The apparent molecular mass of the protein is approximately 102 kDa in SDS-PAGE under reducing conditions due to glycosylation.

NCBI/Uniprot data below describe general gene information for CD176. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
76,724 Da
NCBI Official Full Name
serotransferrin
NCBI Official Synonym Full Names
transferrin
NCBI Official Symbol
NCBI Official Synonym Symbols
HP; Tf; Tfn; hpx; Cd176; AI266983
  [Similar Products]
NCBI Protein Information
serotransferrin
UniProt Protein Name
Serotransferrin
UniProt Synonym Protein Names
Beta-1 metal-binding globulin; Siderophilin
UniProt Gene Name
UniProt Synonym Gene Names
Trf; Transferrin  [Similar Products]
UniProt Comments for CD176
TF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Defects in TF are the cause of atransferrinemia (ATRAF). Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Belongs to the transferrin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9 F1|9 55.03 cM

Cellular Component: apical plasma membrane; basal plasma membrane; basement membrane; cell surface; coated pit; cytoplasmic vesicle; early endosome; endocytic vesicle; endosome; extracellular region; extracellular space; extrinsic to external side of plasma membrane; late endosome; membrane; perinuclear region of cytoplasm; recycling endosome; vesicle

Molecular Function: ferric iron binding; ferrous iron binding; protein binding

Biological Process: actin filament organization; activation of JNK activity; ferric iron transport; iron ion transport; osteoclast differentiation; positive regulation of bone resorption; positive regulation of myelination; positive regulation of phosphorylation; positive regulation of receptor-mediated endocytosis; positive regulation of transcription, DNA-dependent
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withCD176 recombinant protein
 Reference Product  PubMed Publications
 Tfrc recombinant protein  >2 publications with CD176 and Tfrc
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