NP_068693
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
27.6kDa (246aa), confirmed by MALDI-TOF (Molecular size on SDS-PAGE will appear higher)
NCBI Official Full Name
programmed cell death 1 ligand 1
NCBI Official Synonym Full Names
CD274 antigen
NCBI Official Synonym Symbols
B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik [Similar Products]
NCBI Protein Information
programmed cell death 1 ligand 1
UniProt Protein Name
Programmed cell death 1 ligand 1
UniProt Synonym Protein Names
B7 homolog 1; B7-H1; CD_antigen: CD274
UniProt Synonym Gene Names
B7h1; Pdcd1l1; Pdcd1lg1; Pdl1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; B7-H1 [Similar Products]
NCBI Summary for CD274
The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis. [provided by RefSeq, Sep 2015]
UniProt Comments for CD274
Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
Product References and Citations for CD274 recombinant protein
Li,X., et al. (2012) J. Immunol. 188 (2), 724-734; Pulko,V., et al. (2011) J. Immunol. 187 (11), 5606-5614
Research Articles on CD274
Precautions
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Disclaimer
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Products associated with CD274 recombinant protein
Pathways associated with CD274 recombinant protein
Diseases associated with CD274 recombinant protein
Organs/Tissues associated with CD274 recombinant protein
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