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Cd74 recombinant protein :: H-2 class II histocompatibility antigen gamma chain Recombinant Protein

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Catalog # MBS948464
Unit / Price
  0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
  0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
  0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
SDS-PAGE
Product Name

H-2 class II histocompatibility antigen gamma chain (Cd74), Recombinant Protein

Popular Item
Also Known As

Recombinant Rat H-2 class II histocompatibility antigen gamma chain

Product Synonym Names
Ia antigen-associated invariant chain; IiMHC class II-associated invariant chain; CD74
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
57-280aa; Extracellular Domain
Sequence Length
216
Sequence
QQQGRLDKLT VTSQNLQLEN LRMKLPKSAK PVSPMRMATP LLMRPLSMDN MLQAPVKNVT KYGNMTQDHV MHLLTKSGPV NYPQLKGSFP ENLKHLKNSM NGLDWKVFES WMKQWLLFEM SKNSLEEKQP TQTPPKVLTK CQEEVSHIPD VHPGAFRPKC DENGNYMPLQ CHGSTGYCWC VFPNGTEVPH TKSRGRHNCS EPLDMEDPSS GLGVTKQDMG QMFL
3D Structure
ModBase 3D Structure for P10247
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater than 90% as determined by SDS-PAGE. (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Cd74 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Cd74 recombinant protein
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.

Cd74 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for Cd74. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
29.5kD
NCBI Official Full Name
H-2 class II histocompatibility antigen gamma chain
NCBI Official Synonym Full Names
CD74 molecule
NCBI Official Symbol
NCBI Official Synonym Symbols
INVG34
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NCBI Protein Information
H-2 class II histocompatibility antigen gamma chain
UniProt Protein Name
H-2 class II histocompatibility antigen gamma chain
UniProt Synonym Protein Names
Ia antigen-associated invariant chain; Ii; MHC class II-associated invariant chain; CD_antigen: CD74
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
HG2A_RAT
UniProt Comments for Cd74
CD74: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74- ROS1 chimeric protein. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Membrane protein, integral; Receptor, cytokine

Cellular Component: cell surface; endoplasmic reticulum; external side of plasma membrane; Golgi apparatus; integral to membrane; late endosome; lysosome; membrane; MHC class II protein complex; multivesicular body; plasma membrane; vacuole

Molecular Function: beta-amyloid binding; cytokine binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; MHC class II protein binding; MHC class II protein binding, via antigen binding groove; nitric-oxide synthase binding

Biological Process: activation of MAPK activity; antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; cell proliferation; chaperone cofactor-dependent protein folding; defense response; immunoglobulin mediated immune response; intracellular protein transport; negative regulation of apoptosis; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of mature B cell apoptosis; negative regulation of peptide secretion; negative regulation of T cell differentiation; negative thymic T cell selection; positive regulation of B cell proliferation; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of dendritic cell antigen processing and presentation; positive regulation of fibroblast proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of T cell differentiation; positive regulation of T-helper 2 type immune response; positive thymic T cell selection; prostaglandin biosynthetic process; protein complex assembly; signal transduction
Product References and Citations for Cd74 recombinant protein
Sequence of a rat MHC class II-associated invariant chain cDNA clone containing a 64 amino acid thyroglobulin-like domain.McKnight A.J., Mason D.W., Barclay A.N.Nucleic Acids Res. 17:3983-3984(1989) Nucleotide sequence of rat invariant gamma chain cDNA clone pLR gamma 34.3.Henkes W., Syha J., Reske K.Nucleic Acids Res. 16:11822-11822(1988)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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