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anti-cdc25C antibody :: Rabbit anti-Human cdc25C-S216 Antibody

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Catalog # MBS9127445
Unit / Price
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  0.05 mL  /  $235 +1 FREE 8GB USB
  0.1 mL  /  $350 +1 FREE 8GB USB
  0.2 mL  /  $525 +1 FREE 8GB USB
Western Blot (WB)
Product Name

cdc25C-S216, Antibody

Full Product Name

Phospho-cdc25C-S216

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
157680
3D Structure
ModBase 3D Structure for P30307
Host
Rabbit
Species Reactivity
Human
Species
Human
Route
Synthetic Peptide
Other Notes
Small volumes of anti-cdc25C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-cdc25C antibody
Applications Tested/Suitable for anti-cdc25C antibody
Western Blot (WB)

Western Blot (WB) of anti-cdc25C antibody
Western blot analysis of extracts of HT-29 cells, using Phospho-cdc25C-S216 antibody.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% BSA.
anti-cdc25C antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for cdc25C. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
473
NCBI Official Full Name
M-phase inducer phosphatase 3
NCBI Official Synonym Full Names
cell division cycle 25C
NCBI Official Symbol
CDC25C  [Similar Products]
NCBI Official Synonym Symbols
CDC25; PPP1R60
  [Similar Products]
NCBI Protein Information
M-phase inducer phosphatase 3; mitosis inducer CDC25; phosphotyrosine phosphatase; dual specificity phosphatase CDC25C; protein phosphatase 1, regulatory subunit 60
UniProt Protein Name
M-phase inducer phosphatase 3
UniProt Synonym Protein Names
Dual specificity phosphatase Cdc25C
UniProt Gene Name
CDC25C  [Similar Products]
UniProt Entry Name
MPIP3_HUMAN
NCBI Summary for cdc25C
This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. [provided by RefSeq, Jul 2008]
UniProt Comments for cdc25C
CDC25C: a member of the MPI phosphatase family. Activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. Shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. At least four transcript variants for this gene exist. Three splice variant isoforms have been described.

Protein type: Protein phosphatase, dual-specificity; EC 3.1.3.48; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytosol; nucleus

Molecular Function: protein binding; WW domain binding; protein tyrosine phosphatase activity; protein kinase binding

Biological Process: mitosis; cell proliferation; viral reproduction; cell division; regulation of cell cycle; regulation of mitosis; spermatogenesis; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; DNA replication; G2/M transition of mitotic cell cycle
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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