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CDC73 cdna clone

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Catalog # MBS1273132
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
CDC73 cdna clone
Product Name

CDC73, cDNA Clone

Popular Item
Full Product Name

CDC73 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcggacg tgcttagcgt cctgcgacag tacaacatcc agaagaagga gattgtggtg aagggagacg aagtgatctt cggggagttc tcctggccca agaatgtgaa gaccaactat gttgtttggg ggactggaaa ggaaggccaa cccagagagt actacacatt ggattccatt ttatttctac ttaataacgt gcacctttct catcctgttt atgtccgacg tgcagctact gaaaatattc ctgtggttag aagacctgat cgaaaagatc tacttggata tctcaatggt gaagcgtcaa catcggcaag tatagacaga agcgctccct tagaaatagg tcttcagcga tctactcaag tcaaacgagc tgcagatgaa gttttagcag aagcaaagaa accacgaatt gaggatgaag agtgtgtgcg ccttgataaa gagagattgg ctgcccgttt ggagggtcac aaagaaggga ttgtacagac tgaacagatt aggtctttgt ctgaagctat gtcagtggaa aaaattgctg caatcaaagc caaaattatg gctaagaaaa gatctactat caagactgat ctagatgatg acataactgc ccttaaacag aggagttttg tggatgctga ggtagatgtg acccgagata ttgtcagcag agagagagta tggaggacac gaacaactat cttacaaagc acaggaaaga atttttccaa gaacattttt gcaattcttc aatctgtaaa agccagagaa gaagggcgtg cacctgaaca gcgacctgcc ccaaatgcag cacctgtgga tcccactttg cgcaccaaac agcctatccc agctgcctat aacagatacg atcaggaaag attcaaagga aaagaagaaa cggaaggctt caaaattgac actatgggaa cctaccatgg tatgacactg aaatctgtaa cggagggtgc atctgcccgg aagactcaga ctcctgcagc ccagccagta ccaagaccag tttctcaagc aagacctccc ccaaatcaga agaaaggatc tcgaacaccc attatcataa ttcctgcagc taccacctct ttaataacca tgcttaatgc aaaagacctt ctacaggacc tgaaatttgt cccatcagat gaaaagaaga aacaaggttg tcaacgagaa aatgaaactc taatacaaag aagaaaagac cagatgcaac cagggggcac tgcaattagt gttacagtac cttatagagt agtagaccag ccccttaaac ttatgcctca agactgggac cgcgttgtag ccgtttttgt gcagggtcct gcatggcagt tcaaaggttg gccatggctt ttgcctgatg gatcaccagt tgatatattt gctaaaatta aagccttcca tctgaagtat gatgaagttc gtctggatcc aaatgttcag aaatgggatg taacagtatt agaactcagc tatcacaaac gtcatttgga tagaccagtg ttcttacggt tttgggaaac attggacagg tacatggtaa agcataaatc gcacttgaga ttctga
OMIM
145000
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of CDC73 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CDC73. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,577 Da
NCBI Official Full Name
Homo sapiens cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae), mRNA
NCBI Official Synonym Full Names
cell division cycle 73
NCBI Official Symbol
CDC73  [Similar Products]
NCBI Official Synonym Symbols
HYX; FIHP; HPTJT; HRPT1; HRPT2; C1orf28
  [Similar Products]
NCBI Protein Information
parafibromin
UniProt Protein Name
Parafibromin
UniProt Synonym Protein Names
Cell division cycle protein 73 homolog; Hyperparathyroidism 2 protein
UniProt Gene Name
CDC73  [Similar Products]
UniProt Synonym Gene Names
C1orf28; HRPT2  [Similar Products]
UniProt Entry Name
CDC73_HUMAN
NCBI Summary for CDC73
This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009]
UniProt Comments for CDC73
CDC73: Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of MLL1; it promotes leukemogenesis though association with MLL-rearranged oncoproteins, such as MLL-MLLT3/AF9 and MLL-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors. Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61. Interacts with POLR2A, CPSF1, CPSF4, CSTF2, MLL and CTNNB1. Interacts with a Set1-like complex that has histone methyltransferase activity and methylates histone H3. Found in a complex with BCL9L or BCL9, CDC73, CTNNB1 and PYGO1 indicative for the participation in a nuclear Wnt signaling complex. Found in adrenal and parathyroid glands, kidney and heart. Belongs to the CDC73 family.

Protein type: Cell cycle regulation; Tumor suppressor

Chromosomal Location of Human Ortholog: 1q25

Cellular Component: cytoplasm; nuclear chromosome, telomeric region; nucleoplasm; nucleus

Molecular Function: protein binding

Biological Process: endodermal cell fate commitment; histone H2B ubiquitination; histone monoubiquitination; mRNA polyadenylation; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of fibroblast proliferation; negative regulation of myeloid cell differentiation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of mRNA 3'-end processing; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of Wnt receptor signaling pathway; protein destabilization; stem cell maintenance

Disease: Parathyroid Carcinoma
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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