NP_004633.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
9,601 Da
NCBI Official Full Name
cyclin-dependent kinase 2-associated protein 1 isoform 1
NCBI Official Synonym Full Names
cyclin-dependent kinase 2 associated protein 1
NCBI Official Synonym Symbols
DOC1; ST19; DORC1; doc-1; p12DOC-1 [Similar Products]
NCBI Protein Information
cyclin-dependent kinase 2-associated protein 1; Deleted in oral cancer-1; deleted in oral cancer 1; CDK2-associated protein 1; putative oral cancer suppressor
UniProt Protein Name
Cyclin-dependent kinase 2-associated protein 1
UniProt Synonym Protein Names
Deleted in oral cancer 1; DOC-1; Putative oral cancer suppressor
UniProt Synonym Gene Names
UniProt Entry Name
CDKA1_HUMAN
NCBI Summary for CDK2AP1
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
UniProt Comments for CDK2AP1
CDK2AP1: specific inhibitor of the cell-cycle kinase CDK2. Belongs to the CDK2AP family.
Protein type: DNA replication; Tumor suppressor; Cell cycle regulation
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component: perinuclear region of cytoplasm; nucleus
Biological Process: positive regulation of protein amino acid phosphorylation; DNA-dependent DNA replication; cell cycle
Research Articles on CDK2AP1
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