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CDK5RAP3 sirna

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Catalog # MBS8207822
Unit / Price
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  15 nmol  /  $365 +1 FREE 8GB USB
  30 nmol  /  $515 +1 FREE 8GB USB
CDK5RAP3 sirna
Product Name

CDK5RAP3, siRNA

Full Product Name

CDK5RAP3 siRNA (Human)

Product Synonym Names
IC53; CDK5 regulatory subunit-associated protein 3; CDK5 activator-binding protein C53; Protein HSF-27
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
608202
3D Structure
ModBase 3D Structure for Q96JB5
Host
Synthetic
Species Reactivity
Human
Specificity
CDK5RAP3 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
Purity/Purification
> 97%
Form/Format
Lyophilized powder
Quality Control
Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
Directions for Use
We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
Components
We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human CDK5RAP3 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Negative Control
siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
Other Notes
Small volumes of CDK5RAP3 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CDK5RAP3 sirna
siRNA to inhibit CDK5RAP3 expression using RNA interference
Applications Tested/Suitable for CDK5RAP3 sirna
RNA Interference (RNAi)
NCBI/Uniprot data below describe general gene information for CDK5RAP3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,589 Da
NCBI Official Full Name
CDK5 regulatory subunit-associated protein 3 isoform c
NCBI Official Synonym Full Names
CDK5 regulatory subunit associated protein 3
NCBI Official Symbol
CDK5RAP3  [Similar Products]
NCBI Official Synonym Symbols
C53; IC53; LZAP; HSF-27; MST016; PP1553; OK/SW-cl.114
  [Similar Products]
NCBI Protein Information
CDK5 regulatory subunit-associated protein 3
UniProt Protein Name
CDK5 regulatory subunit-associated protein 3
UniProt Synonym Protein Names
CDK5 activator-binding protein C53; LXXLL/leucine-zipper-containing ARF-binding protein
Protein Family
UniProt Gene Name
CDK5RAP3  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
CK5P3_HUMAN
NCBI Summary for CDK5RAP3
This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]
UniProt Comments for CDK5RAP3
CDK5RAP3: Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1. Belongs to the CDK5RAP3 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: protein complex; membrane; cytoplasm; nucleolus; endomembrane system; nucleus

Molecular Function: protein binding; cyclin binding; protein kinase binding

Biological Process: cell proliferation; inhibition of NF-kappaB transcription factor; regulation of neuron differentiation; positive regulation of protein ubiquitination; regulation of mitotic cell cycle; positive regulation of transcription from RNA polymerase II promoter; brain development; regulation of cyclin-dependent protein kinase activity
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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