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anti-CDK6 antibody :: anti-Human, Mouse CDK6 Antibody

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Catalog # MBS856753
Unit / Price
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  0.1 mg  /  $215 +1 FREE 8GB USB
  0.05 mg  /  $225 +1 FREE 8GB USB
Testing Data
Product Name

CDK6, Antibody

Popular Item
Full Product Name

CDK6 (phospho-Tyr13) Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
603368
3D Structure
ModBase 3D Structure for Q00534
Species Reactivity
Human, Mouse
Specificity
CDK6 (phospho-Tyr13) Antibody detects endogenous levels of CDK6 only when phosphorylated at tyrosine 13.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human CDK6 around the phosphorylation site of tyrosine 13 (Q-Q-YP-E-C).
Preparation and Storage
Store at-20 degree C for 1 year
Other Notes
Small volumes of anti-CDK6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CDK6 antibody
Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-CDK6 antibody
IHC: 1:50~100
IF: 1:100~1:200

Testing Data of anti-CDK6 antibody
P-Peptide - +
Immunohistochemical analysis of paraffin-embedded
human breast carcinoma tissue using CDK6 (phospho-Tyr13) Antibody (E011542).
anti-CDK6 antibody Testing Data image
NCBI/Uniprot data below describe general gene information for CDK6. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,938 Da
NCBI Official Full Name
cyclin-dependent kinase 6
NCBI Official Synonym Full Names
cyclin dependent kinase 6
NCBI Official Symbol
NCBI Official Synonym Symbols
MCPH12; PLSTIRE
  [Similar Products]
NCBI Protein Information
cyclin-dependent kinase 6
UniProt Protein Name
Cyclin-dependent kinase 6
UniProt Synonym Protein Names
Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
CDKN6  [Similar Products]
NCBI Summary for CDK6
The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017]
UniProt Comments for CDK6
Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663).
Product References and Citations for anti-CDK6 antibody
Lukas, J. et al. (1996) Mol. Cell. Biol. 16, 6917-1625. Hirai, H. et al. (1995) Mol. Cell. Biol. 15, 2672-2681. Flores-Rozas, H. et al. (1994) Proc. Natl. Acad. Sci. USA 91, 8655-8659.

Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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