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CEBPA recombinant protein :: CCAAT/enhancer-binding protein alpha (CEBPA) Recombinant Protein

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Catalog # MBS1162445
Unit / Price
Scan QR to view Datasheet
  0.05 mg (E-Coli)  /  $765 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $860 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,020 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,090 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,125 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,160 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,315 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,330 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,575 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,700 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,050 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,090 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,160 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $3,170 +3 FREE 8GB USB
CEBPA recombinant protein
Product Name

CCAAT/enhancer-binding protein alpha (CEBPA), Recombinant Protein

Full Product Name

Recombinant Bovine CCAAT/enhancer-binding protein alpha (CEBPA)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-353aa, Full length protein
Sequence
MESADFYEAE PRPPMSSHLQ SPPHAPSSAA FGFPRGAGPS QPPAPPAAPE PLGGICEHET SIDISAYIDP AAFNDEFLAD LFQHSRQQEK AKAAAAPAGG GNDFDYPGAP VGPGGAVMPG GTHGPPPGYG CAAAGYLDSR LEPLYERVGA PALRPLVIKQ EPREEDEAKQ LALAGLFPYQ PPPPPPPPNS HPPPAHLAAP HLQFQIAHCG QTTMHLQPGH PTPPPTPVPS PHPAPALGAA GLPGPGGALK GLVATHPDLR AGGGGGGKAK KSVDKNSNEY RVRRERNNIA VRKSRDKAKQ RNVETQQKVL ELTSDNDRLR KRVEQLSREL DTLRGIFRQL PESSLVKAMG NCA
3D Structure
ModBase 3D Structure for O02754
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Bovine
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CEBPA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CEBPA recombinant protein
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.
NCBI/Uniprot data below describe general gene information for CEBPA. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37,218 Da
NCBI Official Full Name
CCAAT/enhancer-binding protein alpha
NCBI Official Symbol
CEBPA  [Similar Products]
NCBI Protein Information
CCAAT/enhancer-binding protein alpha
UniProt Protein Name
CCAAT/enhancer-binding protein alpha
UniProt Gene Name
CEBPA  [Similar Products]
UniProt Synonym Gene Names
C/EBP alpha  [Similar Products]
UniProt Comments for CEBPA
Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes. During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung. Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage. To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Downregulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex. In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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