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ced-3 recombinant protein :: Cell death protein 3 (ced-3) Recombinant Protein

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Catalog # MBS1084567
Unit / Price
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  0.05 mg (E-Coli)  /  $785 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $875 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,045 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,105 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,155 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,340 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,345 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,595 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,745 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,075 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,125 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,180 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $3,215 +4 FREE 8GB USB
ced-3 recombinant protein
Product Name

Cell death protein 3 (ced-3), Recombinant Protein

Full Product Name

Recombinant Caenorhabditis elegans Cell death protein 3 (ced-3)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-371aa, full length protein
Sequence
MMRQDRRSLL ERNIMMFSSH LKVDEILEVL IAKQVLNSDN GDMINSCGTV REKRREIVKA VQRRGDVAFD AFYDALRSTG HEGLAEVLEP LARSVDSNAV EFECPMSPAS HRRSRALSPA GYTSPTRVHR DSVSSVSSFT SYQDIYSRAR SRSRSRALHS SDRHNYSSPP VNAFPSQPSS ANSSFTGCSS LGYSSSRNRS FSKASGPTQY IFHEEDMNFV DAPTISRVFD EKTMYRNFSS PRGMCLIINN EHFEQMPTRN GTKADKDNLT NLFRCMGYTV ICKDNLTGRG MLLTIRDFAK HESHGDSAIL VILSHGEENV IIGVDDIPIS THEIYDLLNA ANAPRLANKP KIVFVQACRG ERRDNGFPVL D
3D Structure
ModBase 3D Structure for P42573
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Caenorhabditis elegans
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ced-3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ced-3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,617 Da
NCBI Official Full Name
Cell death protein 3 subunit p17
NCBI Official Symbol
ced-3  [Similar Products]
NCBI Protein Information
Cell death protein 3 subunit p17; hypothetical protein
UniProt Protein Name
Cell death protein 3
UniProt Synonym Protein Names
Caspase ced-3Curated
Protein Family
UniProt Gene Name
ced-3  [Similar Products]
UniProt Comments for ced-3
Acts as a cysteine protease in controlling programmed cell death (apoptosis) by proteolytically activating or inactivating a wide range of substrates (PubMed:8654923, PubMed:3955651, PubMed:18722182, PubMed:26074078, PubMed:27723735). Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development (PubMed:3955651, PubMed:17329362, PubMed:25432023, PubMed:27723735). During oogenesis, required for germline apoptosis downstream of ced-9 and ced-4 but independently of egl-1 (PubMed:9927601). By cleaving and activating ced-8, promotes phosphatidylserine exposure on the surface of apoptotic cells; phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment (PubMed:24225442). By cleaving and converting dcr-1 into a deoxyribonuclease (DNase), promotes apoptotic chromosomal DNA fragmentation (PubMed:20223951). By cleaving mitochondrial fission protein drp-1, may regulate the removal of mitochondria during apoptosis (PubMed:18722182). During germline apoptosis, cleaves translation initiation factor ifg-1 (isoform p170) promoting cap-independent translation (PubMed:21909434). During male tail morphogenesis, promotes apoptosis of the tail-spike cell downstream of ced-4 but independently of egl-1 and ced-9 (PubMed:17329362). By cleaving cnt-1, prevents the activation of the prosurvival akt-1/2 signaling pathway and thus promotes apoptosis (PubMed:25383666). Downstream of ced-4, may play a role in sex-specific cell apoptosis by cleaving sex-determining protein fem-1 (PubMed:10764728). May regulate germline apoptosis in response to DNA damage, probably downstream of let-60/ras and mpk-1 pathway (PubMed:21901106). Cleaves ced-9 in vitro (PubMed:17371877, PubMed:18776901, PubMed:19575016, PubMed:25432023, PubMed:27723735). Cleaves csp-2 isoform b resulting in the removal of the propeptide and the generation of csp-2 subunit p31 in vitro (PubMed:9857046). Independently of its apoptotic role has additional functions. Probably by cleaving and thereby activating actin-severing protein gsnl-1, required for the elimination of transient presynaptic components during larval development downstream of egl-1, ced-9 and ced-4 pathway (PubMed:26074078). Together with ain-1, a component of the miRNA-induced-silencing complex (miRISC), regulates temporal cell fate patterning during larval development (PubMed:25432023). Acts in cell fate patterning by cleaving heterochronic protein lin-28, likely promoting its degradation (PubMed:25432023). Also cleaves heterochronic protein lin-14 and exonuclease disl-2 in vitro (PubMed:25432023). Downstream of calreticulin crt-1 and ced-4 and independently of egl-1 and ced-9, plays a role in the initial steps of axonal regrowth following axotomy (PubMed:22629231). Cleaves 14-3-3-like protein ftt-2, tubulin tbb-2 and calrecticulin crt-1 in vitro (PubMed:17371877). Plays also a role in resistance to S.typhimurium-mediated infection (PubMed:11226309).
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with ced-3 recombinant protein
 Reference Product  PubMed Publications
 ced-4 recombinant protein  >111 publications with ced-3 and ced-4
Organs/Tissues associated with ced-3 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Embryo Antibodies  >28 publications with ced-3 and Embryo
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