AAH02703.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,991 Da
NCBI Official Full Name
CENPA protein
NCBI Official Synonym Full Names
centromere protein A
NCBI Protein Information
histone H3-like centromeric protein A; centromere autoantigen A; centromere protein A, 17kDa; centromere-specific histone
UniProt Protein Name
Histone H3-like centromeric protein A
UniProt Synonym Protein Names
Centromere autoantigen A; Centromere protein A
UniProt Synonym Gene Names
UniProt Entry Name
CENPA_HUMAN
NCBI Summary for CENPA
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for CENPA
CENPA: a basic nuclear protein of the histone H3 family. May act as a core histone necessary for the assembly of centromeres. Contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component: nucleoplasm; inner kinetochore of condensed chromosome; nucleosome; nucleus; cytosol; condensed nuclear chromosome, pericentric region; chromosome, pericentric region
Molecular Function: protein binding; DNA binding; protein heterodimerization activity; chromatin binding
Biological Process: nucleosome assembly; kinetochore assembly; DNA replication-independent nucleosome assembly at centromere; viral reproduction; establishment of mitotic spindle orientation; mitotic cell cycle
Research Articles on CENPA
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Products associated with CENPA elisa kit
Pathways associated with CENPA elisa kit
Diseases associated with CENPA elisa kit
Organs/Tissues associated with CENPA elisa kit
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