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anti-CEP135 antibody :: Rabbit anti-Human, mouse CEP135 Antibody

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Catalog # MBS003236
Unit / Price
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  0.1 mL  /  $440 +1 FREE 8GB USB
  0.2 mL  /  $715 +1 FREE 8GB USB
anti-CEP135 antibody
Product Name

CEP135, Antibody

Full Product Name

Rabbit CEP135 Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 4; NC_000004.11 (56814974..56899529). Location: 4q12
OMIM
611423
3D Structure
ModBase 3D Structure for Q66GS9
Host
Rabbit
Species Reactivity
Human, mouse
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Other Notes
Small volumes of anti-CEP135 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CEP135 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for CEP135. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
133,490 Da
NCBI Official Full Name
centrosomal protein of 135 kDa
NCBI Official Synonym Full Names
centrosomal protein 135kDa
NCBI Official Symbol
CEP135  [Similar Products]
NCBI Official Synonym Symbols
CEP4; MCPH8; KIAA0635
  [Similar Products]
NCBI Protein Information
centrosomal protein of 135 kDa; centrosomal protein 4; centrosome protein cep135
UniProt Protein Name
Centrosomal protein of 135 kDa
UniProt Synonym Protein Names
Centrosomal protein 4
Protein Family
UniProt Gene Name
CEP135  [Similar Products]
UniProt Synonym Gene Names
CEP4; KIAA0635; Cep135  [Similar Products]
UniProt Entry Name
CP135_HUMAN
NCBI Summary for CEP135
This gene encodes a centrosomal protein, which acts as a scaffolding protein during early centriole biogenesis, and is also required for centriole-centriole cohesion during interphase. Mutations in this gene are associated with autosomal recessive primary microcephaly-8. [provided by RefSeq, Jun 2012]
UniProt Comments for CEP135
CEP135: Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Defects in CEP135 are the cause of microcephaly, primary, type 8 (MCPH8). MCPH8 is a disease defined as a head circumference more than 3 standard deviations below the age- related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder. Belongs to the CEP135/TSGA10 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 4q12

Cellular Component: centriole; centrosome; cytosol

Molecular Function: protein C-terminus binding; protein binding

Biological Process: organelle organization and biogenesis; centriole replication; mitotic cell cycle; G2/M transition of mitotic cell cycle; centriole-centriole cohesion

Disease: Microcephaly 8, Primary, Autosomal Recessive
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-CEP135 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with CEP135 and Brain
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