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anti-CFAB Bb antibody :: anti-Human, Mouse CFAB Bb Antibody

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Catalog # MBS854690
Unit / Price
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  0.1 mg  /  $215 +1 FREE 8GB USB
Western Blot (WB)
Product Name

CFAB Bb, Antibody

Full Product Name

CFAB Bb (Cleaved-Lys260) Antibody

Product Synonym Names
Complement factor B [Precursor]; EC; C3/C5 convertase; Properdin factor B; Glycine-rich beta glycoprotein; GBG; PBF2; Complement factor B Ba fragment; Complement factor B Bb fragment; CFB; BF; BFD
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P00751
Species Reactivity
Human, Mouse
CFAB Bb (Cleaved-Lys260) antibody detects endogenous levels of fragment of activated CFAB Bb resulting from cleavage adjacent to Lys260.
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
The antiserum was produced against synthesized peptide derived from human CFAB Bb.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-CFAB Bb antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CFAB Bb antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CFAB Bb antibody
WB: 1:500~1:1000
ELISA: 1:20000

Western Blot (WB) of anti-CFAB Bb antibody
Western blot analysis of extracts from K562 cells, treated with etoposide (25uM, 1hour), using CFAB Bb (Cleaved-Lys260) antibody.
anti-CFAB Bb antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for CFAB Bb. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
68,872 Da
NCBI Official Full Name
complement factor B preproprotein
NCBI Official Synonym Full Names
complement factor B
NCBI Official Symbol
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
complement factor B
UniProt Protein Name
Complement factor B
UniProt Synonym Protein Names
C3/C5 convertase; Glycine-rich beta glycoprotein; GBG
UniProt Gene Name
UniProt Synonym Gene Names
BF; BFD; GBG  [Similar Products]
NCBI Summary for CFAB Bb
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]
UniProt Comments for CFAB Bb
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.
Product References and Citations for anti-CFAB Bb antibody
Davrinche C., Immunogenetics 32:309-312(1990). Mejia J.E., Hum. Immunol. 39:49-53(1994). Schwaeble W., Immunobiology 188:221-232(1993).

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Products associated with anti-CFAB Bb antibody
 Reference Product  PubMed Publications
 CFP antibody  >3 publications with CFAB Bb and CFP
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