NP_001091982.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
76,364 Da
NCBI Official Full Name
cGMP-dependent protein kinase 1 isoform 1
NCBI Official Synonym Full Names
protein kinase, cGMP-dependent, type I
NCBI Official Synonym Symbols
1; PKG; cGK; AAT8; cGK1; cGKI; cGK 1; PRKG1B; PRKGR1B; cGKI-BETA; cGKI-alpha [Similar Products]
NCBI Protein Information
cGMP-dependent protein kinase 1; protein kinase, cGMP-dependent, regulatory, type I, beta
UniProt Protein Name
cGMP-dependent protein kinase 1
UniProt Synonym Protein Names
cGMP-dependent protein kinase I
UniProt Synonym Gene Names
UniProt Entry Name
KGP1_HUMAN
NCBI Summary for CGMP
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]
UniProt Comments for CGMP
PKG1: an AGC kinase of the PKG family. Type I cGMP-dependent protein kinase; relaxes vascular smooth muscle and inhibits platelet aggregation. Binding of cGMP results in enzyme activation. Two splice variant isoforms have been described.
Protein type: Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.12; AGC group; PKG family
Chromosomal Location of Human Ortholog: 10q11.2
Cellular Component: Golgi apparatus; cytoplasm; plasma membrane; cytosol
Molecular Function: protein binding; cGMP-dependent protein kinase activity; calcium channel regulator activity; cGMP binding; ATP binding
Biological Process: regulation of GTPase activity; relaxation of vascular smooth muscle; cGMP-mediated signaling; forebrain development; neuron migration; dendrite development; signal transduction; actin cytoskeleton organization and biogenesis; blood coagulation; protein amino acid phosphorylation
Research Articles on CGMP
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Pathways associated with CGMP elisa kit
Diseases associated with CGMP elisa kit
Organs/Tissues associated with CGMP elisa kit
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